Holzgrabe U - Search Results

1

Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.

Bock A, Chirinda B, Krebs F, Messerer R, Bätz J, Muth M, Dallanoce C, Klingenthal D, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K. Bock A, et al. Among authors: holzgrabe u. Nat Chem Biol. 2014 Jan;10(1):18-20. doi: 10.1038/nchembio.1384. Epub 2013 Nov 10. Nat Chem Biol. 2014. PMID: 24212135

2

A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts.

Bejeuhr G, Blaschke G, Holzgrabe U, Mohr K, Sürig U, Terfloth G. Bejeuhr G, et al. Among authors: holzgrabe u. J Pharm Pharmacol. 1994 Feb;46(2):108-12. doi: 10.1111/j.2042-7158.1994.tb03751.x. J Pharm Pharmacol. 1994. PMID: 7912726

3

Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors.

Botero Cid MH, Holzgrabe U, Kostenis E, Mohr K, Tränkle C. Botero Cid MH, et al. Among authors: holzgrabe u. J Med Chem. 1994 May 13;37(10):1439-45. doi: 10.1021/jm00036a008. J Med Chem. 1994. PMID: 8182702

4

Contribution of lateral substituents in heptane-bisammonium derivatives to the allosteric stabilization of antagonist binding to M2-receptors.

Staudt M, Tränkle C, Mohr K, Holzgrabe U. Staudt M, et al. Among authors: holzgrabe u. Life Sci. 1998;62(5):423-9. doi: 10.1016/s0024-3205(97)01135-1. Life Sci. 1998. PMID: 9449232

5

Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.

Tränkle C, Mies-Klomfass E, Cid MH, Holzgrabe U, Mohr K. Tränkle C, et al. Among authors: holzgrabe u. Mol Pharmacol. 1998 Jul;54(1):139-45. doi: 10.1124/mol.54.1.139. Mol Pharmacol. 1998. PMID: 9658199

6

Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.

Nassif-Makki T, Tränkle C, Zlotos D, Bejeuhr G, Cambareri A, Pfletschinger C, Kostenis E, Mohr K, Holzgrabe U. Nassif-Makki T, et al. Among authors: holzgrabe u. J Med Chem. 1999 Mar 11;42(5):849-58. doi: 10.1021/jm981023f. J Med Chem. 1999. PMID: 10072682

7

Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors.

Bender W, Staudt M, Tränkle C, Mohr K, Holzgrabe U. Bender W, et al. Among authors: holzgrabe u. Life Sci. 2000 Mar 24;66(18):1675-82. doi: 10.1016/s0024-3205(00)00490-2. Life Sci. 2000. PMID: 10809164

8

Ligands for the common allosteric site of acetylcholine M2-receptors: development and application.

Holzgrabe U, Bender W, Cid HM, Staudt M, Pick R, Pfletschinger C, Balatková E, Tränkle C, Mohr K. Holzgrabe U, et al. Pharm Acta Helv. 2000 Mar;74(2-3):149-55. doi: 10.1016/s0031-6865(99)00028-x. Pharm Acta Helv. 2000. PMID: 10812952 Review.

9

Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.

Botero Cid HM, Tränkle C, Baumann K, Pick R, Mies-Klomfass E, Kostenis E, Mohr K, Holzgrabe U. Botero Cid HM, et al. Among authors: holzgrabe u. J Med Chem. 2000 Jun 1;43(11):2155-64. doi: 10.1021/jm991136e. J Med Chem. 2000. PMID: 10841794

10

Hexamethonium-type allosteric modulators of the muscarinic receptors bearing lateral dibenzazepine moieties.

Li R, Tränkle C, Mohr K, Holzgrabe U. Li R, et al. Among authors: holzgrabe u. Arch Pharm (Weinheim). 2001 Apr;334(4):121-4. doi: 10.1002/1521-4184(200104)334:4<121::aid-ardp121>3.0.co;2-t. Arch Pharm (Weinheim). 2001. PMID: 11382147

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