Han K - Search Results

1

Parallel measurement of dynamic changes in translation rates in single cells.

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Han K, et al. Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10. Nat Methods. 2014. PMID: 24213167 Free PMC article.

2

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

Gan L, Seki A, Shen K, Iyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer T. Gan L, et al. Among authors: han k. Nat Cell Biol. 2019 May;21(5):614-626. doi: 10.1038/s41556-019-0321-6. Epub 2019 Apr 29. Nat Cell Biol. 2019. PMID: 31036939 Free PMC article.

3

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

Hess GT, Frésard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, Bassik MC. Hess GT, et al. Among authors: han k. Nat Methods. 2016 Dec;13(12):1036-1042. doi: 10.1038/nmeth.4038. Epub 2016 Oct 31. Nat Methods. 2016. PMID: 27798611 Free PMC article.

4

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

Han K, Jeng EE, Hess GT, Morgens DW, Li A, Bassik MC. Han K, et al. Nat Biotechnol. 2017 May;35(5):463-474. doi: 10.1038/nbt.3834. Epub 2017 Mar 20. Nat Biotechnol. 2017. PMID: 28319085 Free PMC article.

5

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens.

Morgens DW, Wainberg M, Boyle EA, Ursu O, Araya CL, Tsui CK, Haney MS, Hess GT, Han K, Jeng EE, Li A, Snyder MP, Greenleaf WJ, Kundaje A, Bassik MC. Morgens DW, et al. Among authors: han k. Nat Commun. 2017 May 5;8:15178. doi: 10.1038/ncomms15178. Nat Commun. 2017. PMID: 28474669 Free PMC article.

6

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV. Breslow DK, et al. Among authors: han k. Nat Genet. 2018 Mar;50(3):460-471. doi: 10.1038/s41588-018-0054-7. Epub 2018 Feb 19. Nat Genet. 2018. PMID: 29459677 Free PMC article.

7

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC. Han K, et al. Nature. 2020 Apr;580(7801):136-141. doi: 10.1038/s41586-020-2099-x. Epub 2020 Mar 11. Nature. 2020. PMID: 32238925 Free PMC article.

8

The N⁶-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.

Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O. Yoshinaga M, et al. Among authors: han k. Nat Commun. 2022 Oct 28;13(1):6435. doi: 10.1038/s41467-022-34078-y. Nat Commun. 2022. PMID: 36307435 Free PMC article.

9

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Hyman JM, et al. Among authors: han k. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. doi: 10.1073/pnas.0907134106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666565 Free PMC article.

10

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK. Cupido T, et al. Among authors: han k. Angew Chem Int Ed Engl. 2009;48(13):2321-4. doi: 10.1002/anie.200805666. Angew Chem Int Ed Engl. 2009. PMID: 19222062

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