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32 results

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Page 1
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
Zhang W, McIver AL, Stashko MA, DeRyckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Zhang W, et al. Among authors: miley mj. J Med Chem. 2013 Dec 12;56(23):9693-700. doi: 10.1021/jm4013888. Epub 2013 Nov 20. J Med Chem. 2013. PMID: 24219778 Free PMC article.
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
Liu J, Yang C, Simpson C, Deryckere D, Van Deusen A, Miley MJ, Kireev D, Norris-Drouin J, Sather S, Hunter D, Korboukh VK, Patel HS, Janzen WP, Machius M, Johnson GL, Earp HS, Graham DK, Frye SV, Wang X. Liu J, et al. Among authors: miley mj. ACS Med Chem Lett. 2012 Feb 9;3(2):129-134. doi: 10.1021/ml200239k. ACS Med Chem Lett. 2012. PMID: 22662287 Free PMC article.
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.
Zhang W, Zhang D, Stashko MA, DeRyckere D, Hunter D, Kireev D, Miley MJ, Cummings C, Lee M, Norris-Drouin J, Stewart WM, Sather S, Zhou Y, Kirkpatrick G, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Zhang W, et al. Among authors: miley mj. J Med Chem. 2013 Dec 12;56(23):9683-92. doi: 10.1021/jm401387j. Epub 2013 Nov 20. J Med Chem. 2013. PMID: 24195762 Free PMC article.
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
Wang X, Liu J, Zhang W, Stashko MA, Nichols J, Miley MJ, Norris-Drouin J, Chen Z, Machius M, DeRyckere D, Wood E, Graham DK, Earp HS, Kireev D, Frye SV. Wang X, et al. Among authors: miley mj. ACS Med Chem Lett. 2016 Sep 13;7(12):1044-1049. doi: 10.1021/acsmedchemlett.6b00221. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994735 Free PMC article.
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
McIver AL, Zhang W, Liu Q, Jiang X, Stashko MA, Nichols J, Miley MJ, Norris-Drouin J, Machius M, DeRyckere D, Wood E, Graham DK, Earp HS, Kireev D, Frye SV, Wang X. McIver AL, et al. Among authors: miley mj. ChemMedChem. 2017 Feb 3;12(3):207-213. doi: 10.1002/cmdc.201600589. Epub 2017 Jan 9. ChemMedChem. 2017. PMID: 28032464 Free PMC article.
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
Da C, Zhang D, Stashko M, Vasileiadi E, Parker RE, Minson KA, Huey MG, Huelse JM, Hunter D, Gilbert TSK, Norris-Drouin J, Miley M, Herring LE, Graves LM, DeRyckere D, Earp HS, Graham DK, Frye SV, Wang X, Kireev D. Da C, et al. J Am Chem Soc. 2019 Oct 2;141(39):15700-15709. doi: 10.1021/jacs.9b08660. Epub 2019 Sep 20. J Am Chem Soc. 2019. PMID: 31497954 Free PMC article.
Computational design of a symmetric homodimer using β-strand assembly.
Stranges PB, Machius M, Miley MJ, Tripathy A, Kuhlman B. Stranges PB, et al. Among authors: miley mj. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20562-7. doi: 10.1073/pnas.1115124108. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143762 Free PMC article.
32 results