Guedes RA - Search Results

1

Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors.

Lucas SD, Gonçalves LM, Carvalho LA, Correia HF, Da Costa EM, Guedes RA, Moreira R, Guedes RC. Lucas SD, et al. Among authors: guedes ra, guedes rc. J Med Chem. 2013 Dec 12;56(23):9802-6. doi: 10.1021/jm4011725. Epub 2013 Nov 20. J Med Chem. 2013. PMID: 24224573

2

3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: inhibition of rat intestinal α-glucosidase.

Carreiro EP, Louro P, Adriano G, Guedes RA, Vannuchi N, Costa AR, Antunes CM, Guedes RC, Burke AJ. Carreiro EP, et al. Among authors: guedes ra, guedes rc. Bioorg Chem. 2014 Jun;54:81-8. doi: 10.1016/j.bioorg.2014.04.007. Epub 2014 Apr 30. Bioorg Chem. 2014. PMID: 24859324

3

Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview.

Guedes RA, Serra P, Salvador JA, Guedes RC. Guedes RA, et al. Among authors: guedes rc. Molecules. 2016 Jul 16;21(7):927. doi: 10.3390/molecules21070927. Molecules. 2016. PMID: 27438821 Free PMC article. Review.

4

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design.

Guedes RA, Aniceto N, Andrade MAP, Salvador JAR, Guedes RC. Guedes RA, et al. Among authors: guedes rc. Int J Mol Sci. 2019 Oct 25;20(21):5326. doi: 10.3390/ijms20215326. Int J Mol Sci. 2019. PMID: 31731563 Free PMC article.

5

Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models.

Alves C, Silva J, Afonso MB, Guedes RA, Guedes RC, Alvariño R, Pinteus S, Gaspar H, Goettert MI, Alfonso A, Rodrigues CMP, Alpoím MC, Botana L, Pedrosa R. Alves C, et al. Among authors: guedes ra. Biomed Pharmacother. 2022 May;149:112886. doi: 10.1016/j.biopha.2022.112886. Epub 2022 Apr 1. Biomed Pharmacother. 2022. PMID: 35378501 Free article.

6

Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance.

Leonardo-Sousa C, Carvalho AN, Guedes RA, Fernandes PMP, Aniceto N, Salvador JAR, Gama MJ, Guedes RC. Leonardo-Sousa C, et al. Among authors: guedes ra. Molecules. 2022 Mar 28;27(7):2201. doi: 10.3390/molecules27072201. Molecules. 2022. PMID: 35408601 Free PMC article. Review.

7

Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action.

Alves C, Silva J, Pintéus S, Guedes RA, Guedes RC, Alvariño R, Freitas R, Goettert MI, Gaspar H, Alfonso A, Alpoím MC, Botana LM, Pedrosa R. Alves C, et al. Among authors: guedes ra. Mar Drugs. 2022 Oct 20;20(10):652. doi: 10.3390/md20100652. Mar Drugs. 2022. PMID: 36286475 Free PMC article.

8

New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies.

Guedes RA, Grilo JH, Carvalho AN, Fernandes PMP, Ressurreição AS, Brito V, Santos AO, Silvestre S, Gallerani E, Gama MJ, Gavioli R, Salvador JAR, Guedes RC. Guedes RA, et al. Pharmaceuticals (Basel). 2023 Aug 2;16(8):1096. doi: 10.3390/ph16081096. Pharmaceuticals (Basel). 2023. PMID: 37631011 Free PMC article.

9

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome.

Fernandes PMP, Guedes RA, Victor BL, Salvador JAR, Guedes RC. Fernandes PMP, et al. Among authors: guedes ra. Front Chem. 2024 Jan 8;11:1322628. doi: 10.3389/fchem.2023.1322628. eCollection 2023. Front Chem. 2024. PMID: 38260042 Free PMC article.

10

Deep generative model for therapeutic targets using transcriptomic disease-associated data-USP7 case study.

Pereira T, Abbasi M, Oliveira RI, Guedes RA, Salvador JAR, Arrais JP. Pereira T, et al. Among authors: guedes ra. Brief Bioinform. 2022 Jul 18;23(4):bbac270. doi: 10.1093/bib/bbac270. Brief Bioinform. 2022. PMID: 35789255

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