Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation.
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PLoS One. 2014 May 21;9(5):e97781. doi: 10.1371/journal.pone.0097781. eCollection 2014.
PLoS One. 2014.
PMID: 24849329
Free PMC article.