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AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia.
Paulus A, Chitta K, Akhtar S, Personett D, Miller KC, Thompson KJ, Carr J, Kumar S, Roy V, Ansell SM, Mikhael JR, Dispenzieri A, Reeder CB, Rivera CE, Foran J, Chanan-Khan A. Paulus A, et al. Among authors: miller kc. Br J Haematol. 2014 Feb;164(3):352-365. doi: 10.1111/bjh.12633. Epub 2013 Nov 17. Br J Haematol. 2014. PMID: 24236538 Free PMC article.
Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.
Masood A, Chitta K, Paulus A, Khan AN, Sher T, Ersing N, Miller KC, Manfredi D, Ailawadhi S, Borrelo I, Lee KP, Chanan-Khan A. Masood A, et al. Among authors: miller kc. Br J Haematol. 2012 Apr;157(1):59-66. doi: 10.1111/j.1365-2141.2011.08984.x. Epub 2011 Dec 15. Br J Haematol. 2012. PMID: 22171982 Free article. Clinical Trial.
Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute - Waldenström Macroglobulinemia 1.
Chitta KS, Paulus A, Ailawadhi S, Foster BA, Moser MT, Starostik P, Masood A, Sher T, Miller KC, Iancu DM, Conroy J, Nowak NJ, Sait SN, Personett DA, Coleman M, Furman RR, Martin P, Ansell SM, Lee K, Chanan-Khan AA. Chitta KS, et al. Among authors: miller kc. Leuk Lymphoma. 2013 Feb;54(2):387-96. doi: 10.3109/10428194.2012.713481. Epub 2012 Aug 27. Leuk Lymphoma. 2013. PMID: 22812491 Free PMC article.
Supportive care in multiple myeloma.
Chanan-Khan A, Miller KC. Chanan-Khan A, et al. Among authors: miller kc. Clin Lymphoma Myeloma. 2006 Jul;7(1):42-50. doi: 10.3816/CLM.2006.n.038. Clin Lymphoma Myeloma. 2006. PMID: 16879769 Review.
119 results