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Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II.
Varney KM, Bonvin AM, Pazgier M, Malin J, Yu W, Ateh E, Oashi T, Lu W, Huang J, Diepeveen-de Buin M, Bryant J, Breukink E, Mackerell AD Jr, de Leeuw EP. Varney KM, et al. Among authors: bonvin am. PLoS Pathog. 2013;9(11):e1003732. doi: 10.1371/journal.ppat.1003732. Epub 2013 Nov 7. PLoS Pathog. 2013. PMID: 24244161 Free PMC article.
Mode of action of teixobactins in cellular membranes.
Shukla R, Medeiros-Silva J, Parmar A, Vermeulen BJA, Das S, Paioni AL, Jekhmane S, Lorent J, Bonvin AMJJ, Baldus M, Lelli M, Veldhuizen EJA, Breukink E, Singh I, Weingarth M. Shukla R, et al. Nat Commun. 2020 Jun 5;11(1):2848. doi: 10.1038/s41467-020-16600-2. Nat Commun. 2020. PMID: 32503964 Free PMC article.
Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II.
Schneider T, Kruse T, Wimmer R, Wiedemann I, Sass V, Pag U, Jansen A, Nielsen AK, Mygind PH, Raventós DS, Neve S, Ravn B, Bonvin AM, De Maria L, Andersen AS, Gammelgaard LK, Sahl HG, Kristensen HH. Schneider T, et al. Among authors: bonvin am. Science. 2010 May 28;328(5982):1168-72. doi: 10.1126/science.1185723. Science. 2010. PMID: 20508130
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. Shukla R, et al. Nature. 2022 Aug;608(7922):390-396. doi: 10.1038/s41586-022-05019-y. Epub 2022 Aug 3. Nature. 2022. PMID: 35922513 Free PMC article.
275 results