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A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines.
Soave M, Cseke G, Hutchings CJ, Brown AJH, Woolard J, Hill SJ. Soave M, et al. Among authors: hutchings cj. Biochem Pharmacol. 2018 Jan;147:38-54. doi: 10.1016/j.bcp.2017.10.015. Epub 2017 Nov 2. Biochem Pharmacol. 2018. PMID: 29102678 Free PMC article.
Ion channels as therapeutic antibody targets.
Hutchings CJ, Colussi P, Clark TG. Hutchings CJ, et al. MAbs. 2019 Feb/Mar;11(2):265-296. doi: 10.1080/19420862.2018.1548232. Epub 2018 Dec 10. MAbs. 2019. PMID: 30526315 Free PMC article. Review.
Discovery and design of G protein-coupled receptor targeting antibodies.
Peterson SM, Hutchings CJ, Hu CF, Mathur M, Salameh JW, Axelrod F, Sato AK. Peterson SM, et al. Among authors: hutchings cj. Expert Opin Drug Discov. 2023 Apr;18(4):417-428. doi: 10.1080/17460441.2023.2193389. Epub 2023 Mar 29. Expert Opin Drug Discov. 2023. PMID: 36992620 Free article.
15 results