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A cell-based reporter assay for screening for EcR agonist/antagonist activity of natural ecdysteroids in Lepidoptera (Bm5) and Diptera (S2) cell cultures, followed by modeling of ecdysteroid-EcR interactions and normal mode analysis.
Zotti MJ, De Geyter E, Swevers L, Braz AS, Scott LP, Rougé P, Coll J, Grutzmacher AD, Lenardão EJ, Smagghe G. Zotti MJ, et al. Among authors: scott lp. Pestic Biochem Physiol. 2013 Nov;107(3):309-20. doi: 10.1016/j.pestbp.2013.09.003. Epub 2013 Sep 26. Pestic Biochem Physiol. 2013. PMID: 24267692
Use of machine learning approaches for novel drug discovery.
Lima AN, Philot EA, Trossini GH, Scott LP, Maltarollo VG, Honorio KM. Lima AN, et al. Among authors: scott lp. Expert Opin Drug Discov. 2016;11(3):225-39. doi: 10.1517/17460441.2016.1146250. Expert Opin Drug Discov. 2016. PMID: 26814169 Review.
80 results