Hallen S - Search Results

1

Structural basis of AMPK regulation by small molecule activators.

Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ. Xiao B, et al. Among authors: hallen s. Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017. Nat Commun. 2013. PMID: 24352254 Free PMC article.

2

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

Lai YC, Kviklyte S, Vertommen D, Lantier L, Foretz M, Viollet B, Hallén S, Rider MH. Lai YC, et al. Among authors: hallen s. Biochem J. 2014 Jun 15;460(3):363-75. doi: 10.1042/BJ20131673. Biochem J. 2014. PMID: 24665903

3

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.

Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallén S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Löfgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Ståhlberg P, Sörme P, Wan H, Wellner E, Oster L. Bengtsson C, et al. Among authors: hallen s. Bioorg Med Chem. 2011 May 15;19(10):3039-53. doi: 10.1016/j.bmc.2011.04.014. Epub 2011 Apr 13. Bioorg Med Chem. 2011. PMID: 21515056

4

Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle.

Plaideau C, Lai YC, Kviklyte S, Zanou N, Löfgren L, Andersén H, Vertommen D, Gailly P, Hue L, Bohlooly-Y M, Hallén S, Rider MH. Plaideau C, et al. Among authors: hallen s. Chem Biol. 2014 Nov 20;21(11):1497-1510. doi: 10.1016/j.chembiol.2014.09.013. Chem Biol. 2014. PMID: 25459662

5

Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes.

Admyre T, Amrot-Fors L, Andersson M, Bauer M, Bjursell M, Drmota T, Hallen S, Hartleib-Geschwindner J, Lindmark B, Liu J, Löfgren L, Rohman M, Selmi N, Wallenius K. Admyre T, et al. Among authors: hallen s. Chem Biol. 2014 Nov 20;21(11):1486-96. doi: 10.1016/j.chembiol.2014.09.011. Chem Biol. 2014. PMID: 25459661

6

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.

Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Peng XR, Mardinoglu A, Spalding KL, Boucher J. Harms MJ, et al. Among authors: hallen s. Cell Rep. 2019 Apr 2;27(1):213-225.e5. doi: 10.1016/j.celrep.2019.03.026. Cell Rep. 2019. PMID: 30943403 Free article.

7

Cell based in vitro and ex vivo models in metabolic disease drug discovery: nice to have or critical path?

Hallén S, Clapham JC. Hallén S, et al. Expert Opin Drug Discov. 2009 Apr;4(4):417-28. doi: 10.1517/17460440902821640. Expert Opin Drug Discov. 2009. PMID: 23485042

8

Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.

Casás-Selves M, Zhang AX, Dowling JE, Hallén S, Kawatkar A, Pace NJ, Denz CR, Pontz T, Garahdaghi F, Cao Q, Sabirsh A, Thakur K, O'Connell N, Hu J, Cornella-Taracido I, Weerapana E, Zinda M, Goodnow RA Jr, Castaldi MP. Casás-Selves M, et al. Among authors: hallen s. ChemMedChem. 2017 Jun 21;12(12):917-924. doi: 10.1002/cmdc.201700028. Epub 2017 Apr 26. ChemMedChem. 2017. PMID: 28371485

9

Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.

Bartesaghi S, Hallen S, Huang L, Svensson PA, Momo RA, Wallin S, Carlsson EK, Forslöw A, Seale P, Peng XR. Bartesaghi S, et al. Among authors: hallen s. Mol Endocrinol. 2015 Jan;29(1):130-9. doi: 10.1210/me.2014-1295. Mol Endocrinol. 2015. PMID: 25389910 Free PMC article.

10

Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity.

Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud PD, Tavernier G, Caspar-Bauguil S, Virtue S, Sramkova V, Monbrun L, Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Monge-Roffarello B, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Bertrand-Michel J, Meugnier E, Ligat L, Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris WHM, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D. Morigny P, et al. Among authors: hallen s. Nat Metab. 2019 Jan;1(1):133-146. doi: 10.1038/s42255-018-0007-6. Epub 2018 Dec 3. Nat Metab. 2019. PMID: 32694809

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