Buckner FS - Search Results

1

Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.

Tatipaka HB, Gillespie JR, Chatterjee AK, Norcross NR, Hulverson MA, Ranade RM, Nagendar P, Creason SA, McQueen J, Duster NA, Nagle A, Supek F, Molteni V, Wenzler T, Brun R, Glynne R, Buckner FS, Gelb MH. Tatipaka HB, et al. Among authors: buckner fs. J Med Chem. 2014 Feb 13;57(3):828-35. doi: 10.1021/jm401178t. Epub 2014 Jan 15. J Med Chem. 2014. PMID: 24354316 Free PMC article.

2

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth.

Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. Yokoyama K, et al. Among authors: buckner fs. Mol Biochem Parasitol. 1998 Jul 1;94(1):87-97. doi: 10.1016/s0166-6851(98)00053-x. Mol Biochem Parasitol. 1998. PMID: 9719512

3

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.

Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Yokoyama K, et al. Among authors: buckner fs. J Biol Chem. 1998 Oct 9;273(41):26497-505. doi: 10.1074/jbc.273.41.26497. J Biol Chem. 1998. PMID: 9756885 Free article.

4

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Aronov AM, et al. Among authors: buckner fs. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8. doi: 10.1073/pnas.96.8.4273. Proc Natl Acad Sci U S A. 1999. PMID: 10200252 Free PMC article.

5

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei.

Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Buckner FS, et al. J Biol Chem. 2000 Jul 21;275(29):21870-6. doi: 10.1074/jbc.M000975200. J Biol Chem. 2000. PMID: 10749864 Free PMC article.

6

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.

Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Bressi JC, et al. Among authors: buckner fs. J Med Chem. 2000 Nov 2;43(22):4135-50. doi: 10.1021/jm000287a. J Med Chem. 2000. PMID: 11063610

7

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Bressi JC, et al. Among authors: buckner fs. J Med Chem. 2001 Jun 21;44(13):2080-93. doi: 10.1021/jm000472o. J Med Chem. 2001. PMID: 11405646 Free PMC article.

8

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

Clerici F, Gelmi ML, Yokoyama K, Pocar D, Van Voorhis WC, Buckner FS, Gelb MH. Clerici F, et al. Among authors: buckner fs. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2217-20. doi: 10.1016/s0960-894x(02)00338-4. Bioorg Med Chem Lett. 2002. PMID: 12127541

9

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF. Gelb MH, et al. Among authors: buckner fs. Mol Biochem Parasitol. 2003 Feb;126(2):155-63. doi: 10.1016/s0166-6851(02)00282-7. Mol Biochem Parasitol. 2003. PMID: 12615314 Review.

10

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

Buckner F, Yokoyama K, Lockman J, Aikenhead K, Ohkanda J, Sadilek M, Sebti S, Van Voorhis W, Hamilton A, Gelb MH. Buckner F, et al. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15149-53. doi: 10.1073/pnas.2535442100. Epub 2003 Dec 1. Proc Natl Acad Sci U S A. 2003. PMID: 14657358 Free PMC article.

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