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Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-Sensitive Magnetic Resonance Imaging and [18F]-DOPA Positron Emission Tomography Study.
Vano LJ, McCutcheon RA, Rutigliano G, Kaar SJ, Finelli V, Nordio G, Wellby G, Sedlacik J, Statton B, Rabiner EA, Ye R, Veronese M, Hopkins SC, Koblan KS, Everall IP, Howes OD. Vano LJ, et al. Among authors: hopkins sc. Biol Psychiatry. 2024 Oct 15;96(8):674-683. doi: 10.1016/j.biopsych.2024.06.013. Epub 2024 Jun 26. Biol Psychiatry. 2024. PMID: 38942349 Free article.
Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Hopkins SC, Toongsuwan S, Corriveau TJ, Watanabe T, Tsushima Y, Asada T, Lew R, Shi L, Zann V, Snowden TJ, van der Graaf PH, Darpo B, Searle GE, Rabiner EA, Wilding I, Szabo ST, Galluppi GR, Koblan KS. Hopkins SC, et al. Clin Pharmacol Ther. 2024 Aug;116(2):460-470. doi: 10.1002/cpt.3311. Epub 2024 May 31. Clin Pharmacol Ther. 2024. PMID: 38822554
Estimating heterogeneity of treatment effect in psychiatric clinical trials.
Siegel JS, Zhong J, Tomioka S, Ogirala A, Faraone SV, Szabo ST, Koblan KS, Hopkins SC. Siegel JS, et al. Among authors: hopkins sc. medRxiv [Preprint]. 2024 Apr 23:2024.04.23.24306211. doi: 10.1101/2024.04.23.24306211. medRxiv. 2024. PMID: 38712180 Free PMC article. Preprint.
TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding.
Dedic N, Wang L, Hajos-Korcsok E, Hecksher-Sørensen J, Roostalu U, Vickers SP, Wu S, Anacker C, Synan C, Jones PG, Milanovic S, Hopkins SC, Bristow LJ, Koblan KS. Dedic N, et al. Among authors: hopkins sc. Mol Metab. 2024 Feb;80:101883. doi: 10.1016/j.molmet.2024.101883. Epub 2024 Jan 16. Mol Metab. 2024. PMID: 38237896 Free PMC article.
A Phase I, Open-Label, Fixed Sequence Study to Investigate the Effect of Cytochrome P450 2D6 Inhibition on the Pharmacokinetics of Ulotaront in Healthy Subjects.
Tsukada H, Chen YL, Xiao G, Lennek L, Milanovic SM, Worden M, Polhamus DG, Chiu YY, Hopkins SC, Galluppi GR. Tsukada H, et al. Among authors: hopkins sc. Clin Pharmacokinet. 2023 Dec;62(12):1755-1763. doi: 10.1007/s40262-023-01317-4. Epub 2023 Oct 26. Clin Pharmacokinet. 2023. PMID: 37882999 Free PMC article.
86 results