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ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.
Widhopf GF 2nd, Cui B, Ghia EM, Chen L, Messer K, Shen Z, Briggs SP, Croce CM, Kipps TJ. Widhopf GF 2nd, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):793-8. doi: 10.1073/pnas.1308374111. Epub 2013 Dec 30. Proc Natl Acad Sci U S A. 2014. PMID: 24379361 Free PMC article.
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.
Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF 2nd, Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA, Kipps TJ. Fukuda T, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3047-52. doi: 10.1073/pnas.0712148105. Epub 2008 Feb 19. Proc Natl Acad Sci U S A. 2008. PMID: 18287027 Free PMC article.
Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia.
Choi MY, Widhopf GF 2nd, Ghia EM, Kidwell RL, Hasan MK, Yu J, Rassenti LZ, Chen L, Chen Y, Pittman E, Pu M, Messer K, Prussak CE, Castro JE, Jamieson C, Kipps TJ. Choi MY, et al. Among authors: chen l, chen y. Cell Stem Cell. 2018 Jun 1;22(6):951-959.e3. doi: 10.1016/j.stem.2018.05.018. Cell Stem Cell. 2018. PMID: 29859176 Free PMC article. Clinical Trial.
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