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Pregnenolone can protect the brain from cannabis intoxication.
Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV. Vallée M, et al. Among authors: lynch dl. Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985. Science. 2014. PMID: 24385629 Free PMC article.
Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.
Schneider M, Kasanetz F, Lynch DL, Friemel CM, Lassalle O, Hurst DP, Steindel F, Monory K, Schäfer C, Miederer I, Leweke FM, Schreckenberger M, Lutz B, Reggio PH, Manzoni OJ, Spanagel R. Schneider M, et al. Among authors: lynch dl. J Neurosci. 2015 Oct 14;35(41):13975-88. doi: 10.1523/JNEUROSCI.1937-15.2015. J Neurosci. 2015. PMID: 26468198 Free PMC article.
TRPV1 Activation by Anandamide via a Unique Lipid Pathway.
Muller C, Lynch DL, Hurst DP, Reggio PH. Muller C, et al. Among authors: lynch dl. J Chem Inf Model. 2021 Dec 27;61(12):5742-5746. doi: 10.1021/acs.jcim.1c00893. Epub 2021 Nov 15. J Chem Inf Model. 2021. PMID: 34780173
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).
Kotsikorou E, Navas F 3rd, Roche MJ, Gilliam AF, Thomas BF, Seltzman HH, Kumar P, Song ZH, Hurst DP, Lynch DL, Reggio PH. Kotsikorou E, et al. Among authors: lynch dl. J Med Chem. 2013 Sep 12;56(17):6593-612. doi: 10.1021/jm400070u. Epub 2013 Aug 14. J Med Chem. 2013. PMID: 23855811 Free PMC article.
74 results