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Page 1
A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Baslanti TO, McKinley BA, Bihorac A, Cuschieri J, Maier RV, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Gentile LF, et al. Among authors: lopez mc. Crit Care Med. 2014 Jun;42(6):1406-13. doi: 10.1097/CCM.0000000000000222. Crit Care Med. 2014. PMID: 24413577 Free PMC article.
Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Mira JC, Szpila BE, Nacionales DC, Lopez MC, Gentile LF, Mathias BJ, Vanzant EL, Ungaro R, Holden D, Rosenthal MD, Rincon J, Verdugo PT, Larson SD, Moore FA, Brakenridge SC, Mohr AM, Baker HV, Moldawer LL, Efron PA. Mira JC, et al. Among authors: lopez mc. Physiol Genomics. 2016 Feb;48(2):135-44. doi: 10.1152/physiolgenomics.00072.2015. Epub 2015 Nov 17. Physiol Genomics. 2016. PMID: 26578697 Free PMC article.
Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.
Lopez MC, Efron PA, Ozrazgat-Baslanti T, Zhang J, Cuschieri J, Maier RV, Minei JP, Baker HV, Moore FA, Moldawer LL, Brakenridge SC. Lopez MC, et al. J Trauma Acute Care Surg. 2016 Sep;81(3):478-85. doi: 10.1097/TA.0000000000001113. J Trauma Acute Care Surg. 2016. PMID: 27306446 Free PMC article.
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
Efron PA, Darden DB, Wang Z, Nacionales DC, Lopez MC, Hawkins RB, Cox MC, Rincon JC, Ungaro R, Dirain ML, Ghita GL, Chen T, Billiar TR, Delano MJ, Leeuwenburgh C, Bihorac A, Brakenridge SC, Moore FA, Mohr AM, Tompkins RG, Brumback BA, Baker HV, Upchurch GR, Moldawer LL. Efron PA, et al. Among authors: lopez mc. FASEB J. 2021 Feb;35(2):e21156. doi: 10.1096/fj.202002150R. Epub 2020 Nov 2. FASEB J. 2021. PMID: 33140449 Free PMC article.
Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.
Darden DB, Mira JC, Lopez MC, Stortz JA, Fenner BP, Kelly LS, Nacionales DC, Budharaju A, Loftus TJ, Baker HV, Moore FA, Brakenridge SC, Moldawer LL, Mohr AM, Efron PA. Darden DB, et al. Among authors: lopez mc. J Trauma Acute Care Surg. 2021 Oct 1;91(4):692-699. doi: 10.1097/TA.0000000000003350. J Trauma Acute Care Surg. 2021. PMID: 34252063 Free PMC article.
Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response.
Winfield RD, Delano MJ, Dixon DJ, Schierding WS, Cendan JC, Lottenberg L, Lopez MC, Baker HV, Cobb JP, Moldawer LL, Maier RV, Cuschieri J. Winfield RD, et al. Among authors: lopez mc. Crit Care Med. 2010 Jan;38(1):51-8. doi: 10.1097/CCM.0b013e3181b08089. Crit Care Med. 2010. PMID: 19661803 Free PMC article.
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.
Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, Seok J, Mindrinos MN, Ang D, Baslanti TO, Bihorac A, Efron PA, Cuschieri J, Warren HS, Tompkins RG, Maier RV, Baker HV, Moldawer LL; Inflammation and Host Response to Injury Collaborative Research Program. Cuenca AG, et al. Among authors: lopez mc. Crit Care Med. 2013 May;41(5):1175-85. doi: 10.1097/CCM.0b013e318277131c. Crit Care Med. 2013. PMID: 23388514 Free PMC article.
Aged mice are unable to mount an effective myeloid response to sepsis.
Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, Ungaro R, Li Y, Baslanti TO, Bihorac A, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Efron PA. Nacionales DC, et al. Among authors: lopez mc. J Immunol. 2014 Jan 15;192(2):612-22. doi: 10.4049/jimmunol.1302109. Epub 2013 Dec 13. J Immunol. 2014. PMID: 24337739 Free PMC article.
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Szpila BE, Larson S, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Gentile LF, et al. Among authors: lopez mc. J Immunol. 2014 Apr 1;192(7):3156-65. doi: 10.4049/jimmunol.1301726. Epub 2014 Mar 3. J Immunol. 2014. PMID: 24591376 Free PMC article.
Host responses to sepsis vary in different low-lethality murine models.
Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Szpila BE, Cuenca AG, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Gentile LF, et al. Among authors: lopez mc. PLoS One. 2014 May 1;9(5):e94404. doi: 10.1371/journal.pone.0094404. eCollection 2014. PLoS One. 2014. PMID: 24788351 Free PMC article.
507 results