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Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I. Aristotelous T, et al. Among authors: navratilova i. ACS Med Chem Lett. 2013 Oct 10;4(10):1005-1010. doi: 10.1021/ml400312j. Epub 2013 Sep 3. ACS Med Chem Lett. 2013. PMID: 24454993 Free PMC article.
Screening for GPCR Ligands Using Surface Plasmon Resonance.
Navratilova I, Besnard J, Hopkins AL. Navratilova I, et al. ACS Med Chem Lett. 2011 Jul 14;2(7):549-554. doi: 10.1021/ml2000017. Epub 2011 May 16. ACS Med Chem Lett. 2011. PMID: 21765967 Free PMC article.
O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis.
Schimpl M, Zheng X, Borodkin VS, Blair DE, Ferenbach AT, Schüttelkopf AW, Navratilova I, Aristotelous T, Albarbarawi O, Robinson DA, Macnaughtan MA, van Aalten DM. Schimpl M, et al. Among authors: navratilova i. Nat Chem Biol. 2012 Dec;8(12):969-74. doi: 10.1038/nchembio.1108. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103942 Free PMC article.
Fragment screening by surface plasmon resonance.
Navratilova I, Hopkins AL. Navratilova I, et al. ACS Med Chem Lett. 2010 Feb 4;1(1):44-8. doi: 10.1021/ml900002k. eCollection 2010 Apr 8. ACS Med Chem Lett. 2010. PMID: 24900174 Free PMC article.
Fragment screening by SPR and advanced application to GPCRs.
Shepherd CA, Hopkins AL, Navratilova I. Shepherd CA, et al. Among authors: navratilova i. Prog Biophys Mol Biol. 2014 Nov-Dec;116(2-3):113-23. doi: 10.1016/j.pbiomolbio.2014.09.008. Epub 2014 Oct 6. Prog Biophys Mol Biol. 2014. PMID: 25301577 Free article. Review.
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
Navratilova I, Aristotelous T, Picaud S, Chaikuad A, Knapp S, Filappakopoulos P, Hopkins AL. Navratilova I, et al. ACS Med Chem Lett. 2016 Sep 20;7(12):1213-1218. doi: 10.1021/acsmedchemlett.6b00154. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994766 Free PMC article.
O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry.
Borodkin VS, Rafie K, Selvan N, Aristotelous T, Navratilova I, Ferenbach AT, van Aalten DMF. Borodkin VS, et al. Among authors: navratilova i. ACS Chem Biol. 2018 May 18;13(5):1353-1360. doi: 10.1021/acschembio.8b00183. Epub 2018 May 2. ACS Chem Biol. 2018. PMID: 29641181 Free PMC article.
43 results