Hou X - Search Results

1

Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.

Nayak A, Chandra G, Hwang I, Kim K, Hou X, Kim HO, Sahu PK, Roy KK, Yoo J, Lee Y, Cui M, Choi S, Moss SM, Phan K, Gao ZG, Ha H, Jacobson KA, Jeong LS. Nayak A, et al. Among authors: hou x. J Med Chem. 2014 Feb 27;57(4):1344-54. doi: 10.1021/jm4015313. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24456490 Free PMC article.

2

Alternative and improved syntheses of highly potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA.

Hou X, Lee HW, Tosh DK, Zhao LX, Jeong LS. Hou X, et al. Arch Pharm Res. 2007 Oct;30(10):1205-9. doi: 10.1007/BF02980260. Arch Pharm Res. 2007. PMID: 18038898

3

First synthesis of 4'-selenonucleosides showing unusual Southern conformation.

Jeong LS, Tosh DK, Kim HO, Wang T, Hou X, Yun HS, Kwon Y, Lee SK, Choi J, Zhao LX. Jeong LS, et al. Among authors: hou x. Org Lett. 2008 Jan 17;10(2):209-12. doi: 10.1021/ol7025558. Epub 2007 Dec 19. Org Lett. 2008. PMID: 18088134

4

Stereoselective synthesis and conformational study of novel 2',3'-Didehydro-2',3'-dideoxy-4'-selenonucleosides.

Tosh DK, Choi WJ, Kim HO, Lee Y, Pal S, Hou X, Choi J, Choi S, Jeong LS. Tosh DK, et al. Among authors: hou x. J Org Chem. 2008 Jun 6;73(11):4259-62. doi: 10.1021/jo8003277. Epub 2008 May 3. J Org Chem. 2008. PMID: 18454552

5

Design and synthesis of truncated 4'-thioadenosine derivatives as potent and selective A3 adenosine receptor antagonists.

Hou X, Pal S, Choi WJ, Kim HO, Tipnis A, Jacobson KA, Jeong LS. Hou X, et al. Nucleic Acids Symp Ser (Oxf). 2008;(52):641-2. doi: 10.1093/nass/nrn324. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776543 Free PMC article.

6

Synthesis of 2-chloro-N6-substituted-4'-thioadenosine-5'-N, N-dialkyluronamides as potent and selective A3 adenosine receptor antagonists.

Choi WJ, Lee HW, Hou X, Kim HO, Jacobson KA, Jeong LS. Choi WJ, et al. Among authors: hou x. Nucleic Acids Symp Ser (Oxf). 2008;(52):645-6. doi: 10.1093/nass/nrn326. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776545 Free PMC article.

7

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.

Jeong LS, Pal S, Choe SA, Choi WJ, Jacobson KA, Gao ZG, Klutz AM, Hou X, Kim HO, Lee HW, Lee SK, Tosh DK, Moon HR. Jeong LS, et al. Among authors: hou x. J Med Chem. 2008 Oct 23;51(20):6609-13. doi: 10.1021/jm8008647. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811138 Free PMC article.

8

Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.

Pal S, Choi WJ, Choe SA, Heller CL, Gao ZG, Chinn M, Jacobson KA, Hou X, Lee SK, Kim HO, Jeong LS. Pal S, et al. Among authors: hou x. Bioorg Med Chem. 2009 May 15;17(10):3733-8. doi: 10.1016/j.bmc.2009.03.034. Epub 2009 Mar 25. Bioorg Med Chem. 2009. PMID: 19375920 Free PMC article.

9

Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.

Hou X, Kim HO, Alexander V, Kim K, Choi S, Park SG, Lee JH, Yoo LS, Gao ZG, Jacobson KA, Jeong LS. Hou X, et al. ACS Med Chem Lett. 2010 Sep 1;2010(9):516-520. doi: 10.1021/ml1001823. ACS Med Chem Lett. 2010. PMID: 21286238 Free PMC article.

10

Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.

Choi MJ, Chandra G, Lee HW, Hou X, Choi WJ, Phan K, Jacobson KA, Jeong LS. Choi MJ, et al. Among authors: hou x. Org Biomol Chem. 2011 Oct 21;9(20):6955-62. doi: 10.1039/c1ob05853c. Epub 2011 Aug 23. Org Biomol Chem. 2011. PMID: 21860878 Free PMC article.

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