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Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis.
Ocaranza MP, Moya J, Barrientos V, Alzamora R, Hevia D, Morales C, Pinto M, Escudero N, García L, Novoa U, Ayala P, Díaz-Araya G, Godoy I, Chiong M, Lavandero S, Jalil JE, Michea L. Ocaranza MP, et al. Among authors: novoa u. J Hypertens. 2014 Apr;32(4):771-83. doi: 10.1097/HJH.0000000000000094. J Hypertens. 2014. PMID: 24463937
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro.
Ocaranza MP, Lavandero S, Jalil JE, Moya J, Pinto M, Novoa U, Apablaza F, Gonzalez L, Hernandez C, Varas M, Lopez R, Godoy I, Verdejo H, Chiong M. Ocaranza MP, et al. Among authors: novoa u. J Hypertens. 2010 May;28(5):1054-64. doi: 10.1097/hjh.0b013e328335d291. J Hypertens. 2010. PMID: 20411619
Angiotensin-(1-9) prevents vascular remodeling by decreasing vascular smooth muscle cell dedifferentiation through a FoxO1-dependent mechanism.
Norambuena-Soto I, Ocaranza MP, Cancino-Arenas N, Sanhueza-Olivares F, Villar-Fincheira P, Leiva-Navarrete S, Mancilla-Medina C, Moya J, Novoa U, Jalil JE, Castro PF, Lavandero S, Chiong M. Norambuena-Soto I, et al. Among authors: novoa u. Biochem Pharmacol. 2020 Oct;180:114190. doi: 10.1016/j.bcp.2020.114190. Epub 2020 Aug 5. Biochem Pharmacol. 2020. PMID: 32768401
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