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Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly.
Sharkey LM, Safren N, Pithadia AS, Gerson JE, Dulchavsky M, Fischer S, Patel R, Lantis G, Ashraf N, Kim JH, Meliki A, Minakawa EN, Barmada SJ, Ivanova MI, Paulson HL. Sharkey LM, et al. Among authors: minakawa en. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10495-E10504. doi: 10.1073/pnas.1810522115. Epub 2018 Oct 17. Proc Natl Acad Sci U S A. 2018. PMID: 30333186 Free PMC article.
Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.
Minakawa EN, Popiel HA, Tada M, Takahashi T, Yamane H, Saitoh Y, Takahashi Y, Ozawa D, Takeda A, Takeuchi T, Okamoto Y, Yamamoto K, Suzuki M, Fujita H, Ito C, Yagihara H, Saito Y, Watase K, Adachi H, Katsuno M, Mochizuki H, Shiraki K, Sobue G, Toda T, Wada K, Onodera O, Nagai Y. Minakawa EN, et al. Brain. 2020 Jun 1;143(6):1811-1825. doi: 10.1093/brain/awaa115. Brain. 2020. PMID: 32436573
Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms.
Tomioka I, Ishibashi H, Minakawa EN, Motohashi HH, Takayama O, Saito Y, Popiel HA, Puentes S, Owari K, Nakatani T, Nogami N, Yamamoto K, Noguchi S, Yonekawa T, Tanaka Y, Fujita N, Suzuki H, Kikuchi H, Aizawa S, Nagano S, Yamada D, Nishino I, Ichinohe N, Wada K, Kohsaka S, Nagai Y, Seki K. Tomioka I, et al. eNeuro. 2017 Mar 28;4(2):ENEURO.0250-16.2017. doi: 10.1523/ENEURO.0250-16.2017. eCollection 2017 Mar-Apr. eNeuro. 2017. PMID: 28374014 Free PMC article.
19 results