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Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development.
Annoura T, van Schaijk BC, Ploemen IH, Sajid M, Lin JW, Vos MW, Dinmohamed AG, Inaoka DK, Rijpma SR, van Gemert GJ, Chevalley-Maurel S, Kiełbasa SM, Scheltinga F, Franke-Fayard B, Klop O, Hermsen CC, Kita K, Gego A, Franetich JF, Mazier D, Hoffman SL, Janse CJ, Sauerwein RW, Khan SM. Annoura T, et al. Among authors: khan sm. FASEB J. 2014 May;28(5):2158-70. doi: 10.1096/fj.13-241570. Epub 2014 Feb 7. FASEB J. 2014. PMID: 24509910
Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.
van Schaijk BC, Janse CJ, van Gemert GJ, van Dijk MR, Gego A, Franetich JF, van de Vegte-Bolmer M, Yalaoui S, Silvie O, Hoffman SL, Waters AP, Mazier D, Sauerwein RW, Khan SM. van Schaijk BC, et al. Among authors: khan sm. PLoS One. 2008;3(10):e3549. doi: 10.1371/journal.pone.0003549. Epub 2008 Oct 28. PLoS One. 2008. PMID: 18958160 Free PMC article.
Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility.
van Dijk MR, van Schaijk BC, Khan SM, van Dooren MW, Ramesar J, Kaczanowski S, van Gemert GJ, Kroeze H, Stunnenberg HG, Eling WM, Sauerwein RW, Waters AP, Janse CJ. van Dijk MR, et al. Among authors: khan sm. PLoS Pathog. 2010 Apr 8;6(4):e1000853. doi: 10.1371/journal.ppat.1000853. PLoS Pathog. 2010. PMID: 20386715 Free PMC article.
Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo.
Fonager J, Pasini EM, Braks JA, Klop O, Ramesar J, Remarque EJ, Vroegrijk IO, van Duinen SG, Thomas AW, Khan SM, Mann M, Kocken CH, Janse CJ, Franke-Fayard BM. Fonager J, et al. Among authors: khan sm. J Exp Med. 2012 Jan 16;209(1):93-107. doi: 10.1084/jem.20110762. Epub 2011 Dec 19. J Exp Med. 2012. PMID: 22184632 Free PMC article.
Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates.
Annoura T, Ploemen IH, van Schaijk BC, Sajid M, Vos MW, van Gemert GJ, Chevalley-Maurel S, Franke-Fayard BM, Hermsen CC, Gego A, Franetich JF, Mazier D, Hoffman SL, Janse CJ, Sauerwein RW, Khan SM. Annoura T, et al. Among authors: khan sm. Vaccine. 2012 Mar 30;30(16):2662-70. doi: 10.1016/j.vaccine.2012.02.010. Epub 2012 Feb 16. Vaccine. 2012. PMID: 22342550
Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.
Lin JW, Meireles P, Prudêncio M, Engelmann S, Annoura T, Sajid M, Chevalley-Maurel S, Ramesar J, Nahar C, Avramut CM, Koster AJ, Matuschewski K, Waters AP, Janse CJ, Mair GR, Khan SM. Lin JW, et al. Among authors: khan sm. Mol Microbiol. 2013 Apr;88(2):318-38. doi: 10.1111/mmi.12187. Epub 2013 Mar 12. Mol Microbiol. 2013. PMID: 23490234 Free article.
A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites.
van Schaijk BC, Ploemen IH, Annoura T, Vos MW, Foquet L, van Gemert GJ, Chevalley-Maurel S, van de Vegte-Bolmer M, Sajid M, Franetich JF, Lorthiois A, Leroux-Roels G, Meuleman P, Hermsen CC, Mazier D, Hoffman SL, Janse CJ, Khan SM, Sauerwein RW. van Schaijk BC, et al. Among authors: khan sm. Elife. 2014 Nov 19;3:e03582. doi: 10.7554/eLife.03582. Elife. 2014. PMID: 25407681 Free PMC article.
553 results