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A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.
Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, He L. Okada N, et al. Among authors: he x, he l, he b. Genes Dev. 2014 Mar 1;28(5):438-50. doi: 10.1101/gad.233585.113. Epub 2014 Feb 14. Genes Dev. 2014. PMID: 24532687 Free PMC article.
miR-34 miRNAs provide a barrier for somatic cell reprogramming.
Choi YJ, Lin CP, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks GG, Hannon GJ, He L. Choi YJ, et al. Among authors: he x, he l. Nat Cell Biol. 2011 Oct 23;13(11):1353-60. doi: 10.1038/ncb2366. Nat Cell Biol. 2011. PMID: 22020437 Free PMC article.
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts.
Xue B, Chuang CH, Prosser HM, Fuziwara CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L. Xue B, et al. Among authors: he l. Genes Dev. 2021 Aug 1;35(15-16):1109-1122. doi: 10.1101/gad.347344.120. Epub 2021 Jul 22. Genes Dev. 2021. PMID: 34301766 Free PMC article.
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L. Olive V, et al. Among authors: he l. Elife. 2013 Oct 15;2:e00822. doi: 10.7554/eLife.00822. Elife. 2013. PMID: 24137534 Free PMC article.
miR-19 is a key oncogenic component of mir-17-92.
Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ, He L. Olive V, et al. Among authors: he l. Genes Dev. 2009 Dec 15;23(24):2839-49. doi: 10.1101/gad.1861409. Genes Dev. 2009. PMID: 20008935 Free PMC article.
Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells.
Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L. Choi YJ, et al. Among authors: he l. Science. 2017 Feb 10;355(6325):eaag1927. doi: 10.1126/science.aag1927. Epub 2017 Jan 12. Science. 2017. PMID: 28082412 Free PMC article.
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