Chibale K - Search Results

1

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

Le Manach C, Gonzàlez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ, Chibale K. Le Manach C, et al. Among authors: chibale k. J Med Chem. 2014 Mar 27;57(6):2789-98. doi: 10.1021/jm500098s. Epub 2014 Mar 13. J Med Chem. 2014. PMID: 24568587

2

Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides.

Chibale K, Ojima I, Haupt H, Geng X, Pera P, Bernacki RJ. Chibale K, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2457-60. doi: 10.1016/s0960-894x(01)00462-0. Bioorg Med Chem Lett. 2001. PMID: 11549446

3

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.

Chibale K, Haupt H, Kendrick H, Yardley V, Saravanamuthu A, Fairlamb AH, Croft SL. Chibale K, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2655-7. doi: 10.1016/s0960-894x(01)00528-5. Bioorg Med Chem Lett. 2001. PMID: 11551771

4

The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors.

Chibale K, Musonda CC. Chibale K, et al. Curr Med Chem. 2003 Sep;10(18):1863-89. doi: 10.2174/0929867033456963. Curr Med Chem. 2003. PMID: 12871109 Review.

5

Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.

Clarkson C, Musonda CC, Chibale K, Campbell WE, Smith P. Clarkson C, et al. Among authors: chibale k. Bioorg Med Chem. 2003 Oct 1;11(20):4417-22. doi: 10.1016/s0968-0896(03)00491-7. Bioorg Med Chem. 2003. PMID: 13129578

6

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3901-5. doi: 10.1016/j.bmcl.2004.05.063. Bioorg Med Chem Lett. 2004. PMID: 15225694

7

Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery.

Musonda CC, Chibale K. Musonda CC, et al. Among authors: chibale k. Curr Med Chem. 2004 Oct;11(19):2519-33. doi: 10.2174/0929867043364469. Curr Med Chem. 2004. PMID: 15544460 Review.

8

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Chiyanzu I, et al. Among authors: chibale k. Bioorg Med Chem. 2005 May 2;13(9):3249-61. doi: 10.1016/j.bmc.2005.02.037. Bioorg Med Chem. 2005. PMID: 15809160

9

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.

Chouteau F, Ramanitrahasimbola D, Rasoanaivo P, Chibale K. Chouteau F, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3024-8. doi: 10.1016/j.bmcl.2005.04.033. Bioorg Med Chem Lett. 2005. PMID: 15908208

10

Reversal of chloroquine resistance in Plasmodium falciparum by 9H-xanthene derivatives.

Wu CP, van Schalkwyk DA, Taylor D, Smith PJ, Chibale K. Wu CP, et al. Among authors: chibale k. Int J Antimicrob Agents. 2005 Aug;26(2):170-5. doi: 10.1016/j.ijantimicag.2005.04.018. Int J Antimicrob Agents. 2005. PMID: 16009536

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