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Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.
Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J, Hart LS, Levi S, Hu J, Zhang G, Lazova R, Klump V, Pawelek JM, Xu X, Xu W, Schuchter LM, Davies MA, Herlyn M, Winkler J, Koumenis C, Amaravadi RK. Ma XH, et al. Among authors: winkler j. J Clin Invest. 2014 Mar;124(3):1406-17. doi: 10.1172/JCI70454. Epub 2014 Feb 24. J Clin Invest. 2014. PMID: 24569374 Free PMC article.
Identification of a novel family of BRAF(V600E) inhibitors.
Qin J, Xie P, Ventocilla C, Zhou G, Vultur A, Chen Q, Liu Q, Herlyn M, Winkler J, Marmorstein R. Qin J, et al. Among authors: winkler j. J Med Chem. 2012 Jun 14;55(11):5220-30. doi: 10.1021/jm3004416. Epub 2012 May 18. J Med Chem. 2012. PMID: 22537109 Free PMC article.
Lys05: a new lysosomal autophagy inhibitor.
Amaravadi RK, Winkler JD. Amaravadi RK, et al. Autophagy. 2012 Sep;8(9):1383-4. doi: 10.4161/auto.20958. Epub 2012 Aug 10. Autophagy. 2012. PMID: 22878685 Free PMC article.
Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma.
DeVorkin L, Hattersley M, Kim P, Ries J, Spowart J, Anglesio MS, Levi SM, Huntsman DG, Amaravadi RK, Winkler JD, Tinker AV, Lum JJ. DeVorkin L, et al. Among authors: winkler jd. Mol Cancer Res. 2017 Mar;15(3):250-258. doi: 10.1158/1541-7786.MCR-16-0132. Epub 2017 Feb 9. Mol Cancer Res. 2017. PMID: 28184014 Free PMC article.
Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma.
Gade TPF, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC. Gade TPF, et al. Among authors: winkler jd. Radiology. 2017 Jun;283(3):702-710. doi: 10.1148/radiol.2017160728. Epub 2017 Mar 2. Radiology. 2017. PMID: 28253108 Free PMC article.
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.
Vijayaraghavan S, Karakas C, Doostan I, Chen X, Bui T, Yi M, Raghavendra AS, Zhao Y, Bashour SI, Ibrahim NK, Karuturi M, Wang J, Winkler JD, Amaravadi RK, Hunt KK, Tripathy D, Keyomarsi K. Vijayaraghavan S, et al. Among authors: winkler jd. Nat Commun. 2017 Jun 27;8:15916. doi: 10.1038/ncomms15916. Nat Commun. 2017. PMID: 28653662 Free PMC article.
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
Ndoye A, Budina-Kolomets A, Kugel CH 3rd, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Gopal YNV, Davies MA, Mills GB, Xu X, Wu H, Herlyn M, Nicastri MC, Winkler JD, Soengas MS, Amaravadi RK, Murphy ME, Weeraratna AT. Ndoye A, et al. Cancer Res. 2017 Nov 1;77(21):5873-5885. doi: 10.1158/0008-5472.CAN-17-0907. Epub 2017 Sep 8. Cancer Res. 2017. PMID: 28887323 Free PMC article.
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. Rebecca VW, et al. Among authors: winkler jd. Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12. Cancer Discov. 2017. PMID: 28899863 Free PMC article.
1,567 results