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The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.
Humbert M, Federzoni EA, Britschgi A, Schläfli AM, Valk PJ, Kaufmann T, Haferlach T, Behre G, Simon HU, Torbett BE, Fey MF, Tschan MP. Humbert M, et al. Among authors: behre g. J Leukoc Biol. 2014 Jan;95(1):83-93. doi: 10.1189/jlb.1112608. Epub 2013 Sep 13. J Leukoc Biol. 2014. PMID: 24038216 Free PMC article.
C/EBPα deregulation as a paradigm for leukemogenesis.
Pulikkan JA, Tenen DG, Behre G. Pulikkan JA, et al. Among authors: behre g. Leukemia. 2017 Nov;31(11):2279-2285. doi: 10.1038/leu.2017.229. Epub 2017 Jul 19. Leukemia. 2017. PMID: 28720765 Free PMC article. Review.
Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.
Wurm AA, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Benoukraf T, Fricke S, Hilger N, Müller AM, Bill M, Schwind S, Tenen DG, Niederwieser D, Alberich-Jorda M, Behre G. Wurm AA, et al. Among authors: behre g. Nat Commun. 2017 Jun 29;8(1):46. doi: 10.1038/s41467-017-00032-6. Nat Commun. 2017. PMID: 28663557 Free PMC article.
EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.
Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, Brdicka T, Tenen DG, Behre G, Fiore F, Malissen B, Horejsi V, Alberich-Jorda M. Zjablovskaja P, et al. Among authors: behre g. Cell Death Differ. 2017 Apr;24(4):705-716. doi: 10.1038/cdd.2017.6. Epub 2017 Feb 10. Cell Death Differ. 2017. PMID: 28186500 Free PMC article.
117 results