Chang WC - Search Results

1

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics.

Chang WC, Guo Y, Wang C, Butch SE, Rosenzweig AC, Boal AK, Krebs C, Bollinger JM Jr. Chang WC, et al. Science. 2014 Mar 7;343(6175):1140-4. doi: 10.1126/science.1248000. Science. 2014. PMID: 24604200 Free PMC article.

2

Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases.

Li N, Chang WC, Warui DM, Booker SJ, Krebs C, Bollinger JM Jr. Li N, et al. Among authors: chang wc. Biochemistry. 2012 Oct 9;51(40):7908-16. doi: 10.1021/bi300912n. Epub 2012 Sep 24. Biochemistry. 2012. PMID: 22947199

3

Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate.

Pandelia ME, Li N, Nørgaard H, Warui DM, Rajakovich LJ, Chang WC, Booker SJ, Krebs C, Bollinger JM Jr. Pandelia ME, et al. Among authors: chang wc. J Am Chem Soc. 2013 Oct 23;135(42):15801-12. doi: 10.1021/ja405047b. Epub 2013 Oct 9. J Am Chem Soc. 2013. PMID: 23987523 Free PMC article.

4

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase.

Wang C, Chang WC, Guo Y, Huang H, Peck SC, Pandelia ME, Lin GM, Liu HW, Krebs C, Bollinger JM Jr. Wang C, et al. Among authors: chang wc. Science. 2013 Nov 22;342(6161):991-5. doi: 10.1126/science.1240373. Epub 2013 Oct 10. Science. 2013. PMID: 24114783 Free PMC article.

5

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase.

Matthews ML, Chang WC, Layne AP, Miles LA, Krebs C, Bollinger JM Jr. Matthews ML, et al. Among authors: chang wc. Nat Chem Biol. 2014 Mar;10(3):209-15. doi: 10.1038/nchembio.1438. Epub 2014 Jan 26. Nat Chem Biol. 2014. PMID: 24463698 Free PMC article.

6

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2.

Martinie RJ, Livada J, Chang WC, Green MT, Krebs C, Bollinger JM Jr, Silakov A. Martinie RJ, et al. Among authors: chang wc. J Am Chem Soc. 2015 Jun 3;137(21):6912-9. doi: 10.1021/jacs.5b03370. Epub 2015 May 19. J Am Chem Soc. 2015. PMID: 25965587 Free PMC article.

7

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism.

Rajakovich LJ, Nørgaard H, Warui DM, Chang WC, Li N, Booker SJ, Krebs C, Bollinger JM Jr, Pandelia ME. Rajakovich LJ, et al. Among authors: chang wc. J Am Chem Soc. 2015 Sep 16;137(36):11695-709. doi: 10.1021/jacs.5b06345. Epub 2015 Sep 2. J Am Chem Soc. 2015. PMID: 26284355

8

Assembly of the unusual oxacycles in the orthosomycin antibiotics.

Boal AK, Bollinger JM Jr, Chang WC. Boal AK, et al. Among authors: chang wc. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):11989-90. doi: 10.1073/pnas.1514689112. Epub 2015 Sep 16. Proc Natl Acad Sci U S A. 2015. PMID: 26378126 Free PMC article. No abstract available.

9

Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase.

Tamanaha E, Zhang B, Guo Y, Chang WC, Barr EW, Xing G, St Clair J, Ye S, Neese F, Bollinger JM Jr, Krebs C. Tamanaha E, et al. Among authors: chang wc. J Am Chem Soc. 2016 Jul 20;138(28):8862-74. doi: 10.1021/jacs.6b04065. Epub 2016 Jul 5. J Am Chem Soc. 2016. PMID: 27193226 Free PMC article.

10

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4'-Methoxycyclopenin Biosynthesis.

Chang WC, Li J, Lee JL, Cronican AA, Guo Y. Chang WC, et al. J Am Chem Soc. 2016 Aug 24;138(33):10390-3. doi: 10.1021/jacs.6b05400. Epub 2016 Aug 11. J Am Chem Soc. 2016. PMID: 27442345

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