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BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.
Savage KI, Matchett KB, Barros EM, Cooper KM, Irwin GW, Gorski JJ, Orr KS, Vohhodina J, Kavanagh JN, Madden AF, Powell A, Manti L, McDade SS, Park BH, Prise KM, McIntosh SA, Salto-Tellez M, Richard DJ, Elliott CT, Harkin DP. Savage KI, et al. Among authors: mcintosh sa. Cancer Res. 2014 May 15;74(10):2773-2784. doi: 10.1158/0008-5472.CAN-13-2611. Epub 2014 Mar 17. Cancer Res. 2014. PMID: 24638981 Free PMC article.
Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression.
Stupnikov A, O'Reilly PG, McInerney CE, Roddy AC, Dunne PD, Gilmore A, Ellis HP, Flannery T, Healy E, McIntosh SA, Savage K, Kurian KM, Emmert-Streib F, Prise KM, Salto-Tellez M, McArt DG. Stupnikov A, et al. Among authors: mcintosh sa. JCO Precis Oncol. 2018 Sep 13;2:PO.18.00014. doi: 10.1200/PO.18.00014. JCO Precis Oncol. 2018. PMID: 30324181 Free PMC article.
Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment.
Campbell AM, Morris M, Gallagher R, Boyd R, Carson H, Harkin DP, Wielogorska E, Elliott C, Savage KI, McIntosh SA. Campbell AM, et al. Among authors: mcintosh sa. BMJ Open. 2018 Dec 22;8(12):e023115. doi: 10.1136/bmjopen-2018-023115. BMJ Open. 2018. PMID: 30580266 Free PMC article. Clinical Trial.
Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers.
McCrorie AD, Ashfield S, Begley A, Mcilmunn C, Morrison PJ, Boyd C, Eccles B, Greville-Heygate S, Copson ER, Cutress RI, Eccles DM, Savage KI, McIntosh SA. McCrorie AD, et al. Among authors: mcintosh sa. J Pathol Clin Res. 2020 Apr;6(2):146-153. doi: 10.1002/cjp2.155. Epub 2020 Feb 5. J Pathol Clin Res. 2020. PMID: 32022473 Free PMC article.
Robustness of differential gene expression analysis of RNA-seq.
Stupnikov A, McInerney CE, Savage KI, McIntosh SA, Emmert-Streib F, Kennedy R, Salto-Tellez M, Prise KM, McArt DG. Stupnikov A, et al. Among authors: mcintosh sa. Comput Struct Biotechnol J. 2021 May 26;19:3470-3481. doi: 10.1016/j.csbj.2021.05.040. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34188784 Free PMC article.
Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer.
Parkes EE, Savage KI, Lioe T, Boyd C, Halliday S, Walker SM, Lowry K, Knight L, Buckley NE, Grogan A, Logan GE, Clayton A, Hurwitz J, Kirk SJ, Xu J, Sidi FA, Humphries MP, Bingham V; Neo-DDIR Investigators; James JA, James CR, Paul Harkin D, Kennedy RD, McIntosh SA. Parkes EE, et al. Among authors: mcintosh sa. Br J Cancer. 2022 Feb;126(2):247-258. doi: 10.1038/s41416-021-01599-0. Epub 2021 Nov 2. Br J Cancer. 2022. PMID: 34728791 Free PMC article.
Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway.
McClements L, Yakkundi A, Papaspyropoulos A, Harrison H, Ablett MP, Jithesh PV, McKeen HD, Bennett R, Donley C, Kissenpfennig A, McIntosh S, McCarthy HO, O'Neill E, Clarke RB, Robson T. McClements L, et al. Clin Cancer Res. 2013 Jul 15;19(14):3881-93. doi: 10.1158/1078-0432.CCR-13-0595. Epub 2013 Jun 5. Clin Cancer Res. 2013. PMID: 23741069
Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK 'Alert Level 4' phase of the B-MaP-C study.
Dave RV, Kim B, Courtney A, O'Connell R, Rattay T, Taxiarchi VP, Kirkham JJ, Camacho EM, Fairbrother P, Sharma N, Cartlidge CWJ, Horgan K, McIntosh SA, Leff DR, Vidya R, Potter S, Holcombe C, Copson E, Coles CE, Cutress RI, Gandhi A, Kirwan CC; B-MaP-C study collaborative. Dave RV, et al. Among authors: mcintosh sa. Br J Cancer. 2021 May;124(11):1785-1794. doi: 10.1038/s41416-020-01234-4. Epub 2021 Mar 25. Br J Cancer. 2021. PMID: 33767422 Free PMC article.
83 results