Olini GC - Search Results

1

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Shi Q, Tebben A, Dyckman AJ, Li H, Liu C, Lin J, Spergel S, Burke JR, McIntyre KW, Olini GC, Strnad J, Surti N, Muckelbauer JK, Chang C, An Y, Cheng L, Ruan Q, Leftheris K, Carter PH, Tino J, De Lucca GV. Shi Q, et al. Among authors: olini gc. Bioorg Med Chem Lett. 2014 May 1;24(9):2206-11. doi: 10.1016/j.bmcl.2014.02.075. Epub 2014 Mar 13. Bioorg Med Chem Lett. 2014. PMID: 24685542

2

Inhibitors of unactivated p38 MAP kinase.

Bullington J, Argentieri D, Averill K, Carter D, Cavender D, Fahmy B, Fan X, Hall D, Heintzelman G, Jackson P, Leung WP, Li X, Ling P, Olini G, Razler T, Reuman M, Rupert K, Russell R, Siekierka J, Wadsworth S, Wolff R, Xiang B, Zhang YM. Bullington J, et al. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6102-6. doi: 10.1016/j.bmcl.2006.08.101. Epub 2006 Sep 12. Bioorg Med Chem Lett. 2006. PMID: 16971122

3

Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists.

Xia M, Hou C, Pollack S, Brackley J, DeMong D, Pan M, Singer M, Matheis M, Olini G, Cavender D, Wachter M. Xia M, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5964-8. doi: 10.1016/j.bmcl.2007.07.065. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17869105

4

Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma.

Lagu B, Gerchak C, Pan M, Hou C, Singer M, Malaviya R, Matheis M, Olini G, Cavender D, Wachter M. Lagu B, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4382-6. doi: 10.1016/j.bmcl.2007.01.115. Epub 2007 Feb 8. Bioorg Med Chem Lett. 2007. PMID: 17587570

5

Imidazopyrimidines, potent inhibitors of p38 MAP kinase.

Rupert KC, Henry JR, Dodd JH, Wadsworth SA, Cavender DE, Olini GC, Fahmy B, Siekierka JJ. Rupert KC, et al. Among authors: olini gc. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50. doi: 10.1016/s0960-894x(02)01020-x. Bioorg Med Chem Lett. 2003. PMID: 12565927

6

Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists.

Xia M, Hou C, DeMong DE, Pollack SR, Pan M, Brackley JA, Jain N, Gerchak C, Singer M, Malaviya R, Matheis M, Olini G, Cavender D, Wachter M. Xia M, et al. J Med Chem. 2007 Nov 15;50(23):5561-3. doi: 10.1021/jm070902b. Epub 2007 Oct 11. J Med Chem. 2007. PMID: 17929797

7

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor.

Henry JR, Rupert KC, Dodd JH, Turchi IJ, Wadsworth SA, Cavender DE, Fahmy B, Olini GC, Davis JE, Pellegrino-Gensey JL, Schafer PH, Siekierka JJ. Henry JR, et al. Among authors: olini gc. J Med Chem. 1998 Oct 22;41(22):4196-8. doi: 10.1021/jm980497b. J Med Chem. 1998. PMID: 9784093 No abstract available.

8

Targeting cytosolic phospholipase A2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice.

Malaviya R, Ansell J, Hall L, Fahmy M, Argentieri RL, Olini GC Jr, Pereira DW, Sur R, Cavender D. Malaviya R, et al. Among authors: olini gc jr. Eur J Pharmacol. 2006 Jun 13;539(3):195-204. doi: 10.1016/j.ejphar.2006.03.018. Epub 2006 Mar 20. Eur J Pharmacol. 2006. PMID: 16712837

9

Development of a sensitive and HTS-compatible reporter gene assay for functional analysis of human adenosine A2a receptors in CHO-K1 cells.

Tang Y, Luo J, Fleming CR, Kong Y, Olini GC Jr, Wildey MJ, Cavender DE, Demarest KT. Tang Y, et al. Among authors: olini gc jr. Assay Drug Dev Technol. 2004 Jun;2(3):281-9. doi: 10.1089/1540658041410650. Assay Drug Dev Technol. 2004. PMID: 15285909

10

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

Wadsworth SA, Cavender DE, Beers SA, Lalan P, Schafer PH, Malloy EA, Wu W, Fahmy B, Olini GC, Davis JE, Pellegrino-Gensey JL, Wachter MP, Siekierka JJ. Wadsworth SA, et al. Among authors: olini gc. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7. J Pharmacol Exp Ther. 1999. PMID: 10525088

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