Fu H - Search Results

1

Feasibility and safety of systemic rAAV9-hNAGLU delivery for treating mucopolysaccharidosis IIIB: toxicology, biodistribution, and immunological assessments in primates.

Murrey DA, Naughton BJ, Duncan FJ, Meadows AS, Ware TA, Campbell KJ, Bremer WG, Walker CM, Goodchild L, Bolon B, La Perle K, Flanigan KM, McBride KL, McCarty DM, Fu H. Murrey DA, et al. Among authors: fu h. Hum Gene Ther Clin Dev. 2014 Jun;25(2):72-84. doi: 10.1089/humc.2013.208. Epub 2014 Apr 10. Hum Gene Ther Clin Dev. 2014. PMID: 24720466 Free PMC article.

2

Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery.

Fu H, Samulski RJ, McCown TJ, Picornell YJ, Fletcher D, Muenzer J. Fu H, et al. Mol Ther. 2002 Jan;5(1):42-9. doi: 10.1006/mthe.2001.0514. Mol Ther. 2002. PMID: 11786044 Free article.

3

Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo.

McCarty DM, Fu H, Monahan PE, Toulson CE, Naik P, Samulski RJ. McCarty DM, et al. Among authors: fu h. Gene Ther. 2003 Dec;10(26):2112-8. doi: 10.1038/sj.gt.3302134. Gene Ther. 2003. PMID: 14625565

4

Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain.

Fu H, Muenzer J, Samulski RJ, Breese G, Sifford J, Zeng X, McCarty DM. Fu H, et al. Mol Ther. 2003 Dec;8(6):911-7. doi: 10.1016/j.ymthe.2003.08.021. Mol Ther. 2003. PMID: 14664793 Free article.

5

Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice.

Fu H, Kang L, Jennings JS, Moy SS, Perez A, Dirosario J, McCarty DM, Muenzer J. Fu H, et al. Gene Ther. 2007 Jul;14(14):1065-77. doi: 10.1038/sj.gt.3302961. Epub 2007 Apr 26. Gene Ther. 2007. PMID: 17460717

6

Innate and adaptive immune activation in the brain of MPS IIIB mouse model.

DiRosario J, Divers E, Wang C, Etter J, Charrier A, Jukkola P, Auer H, Best V, Newsom DL, McCarty DM, Fu H. DiRosario J, et al. Among authors: fu h. J Neurosci Res. 2009 Mar;87(4):978-90. doi: 10.1002/jnr.21912. J Neurosci Res. 2009. PMID: 18951493

7

Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice.

McCarty DM, DiRosario J, Gulaid K, Muenzer J, Fu H. McCarty DM, et al. Among authors: fu h. Gene Ther. 2009 Nov;16(11):1340-52. doi: 10.1038/gt.2009.85. Epub 2009 Jul 9. Gene Ther. 2009. PMID: 19587708 Free PMC article.

8

Restoration of central nervous system alpha-N-acetylglucosaminidase activity and therapeutic benefits in mucopolysaccharidosis IIIB mice by a single intracisternal recombinant adeno-associated viral type 2 vector delivery.

Fu H, DiRosario J, Kang L, Muenzer J, McCarty DM. Fu H, et al. J Gene Med. 2010 Jul;12(7):624-33. doi: 10.1002/jgm.1480. J Gene Med. 2010. PMID: 20603889

9

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response.

Killedar S, Dirosario J, Divers E, Popovich PG, McCarty DM, Fu H. Killedar S, et al. Among authors: fu h. J Neuroinflammation. 2010 Jul 16;7:39. doi: 10.1186/1742-2094-7-39. J Neuroinflammation. 2010. PMID: 20637096 Free PMC article.

10

Differential distribution of heparan sulfate glycoforms and elevated expression of heparan sulfate biosynthetic enzyme genes in the brain of mucopolysaccharidosis IIIB mice.

McCarty DM, DiRosario J, Gulaid K, Killedar S, Oosterhof A, van Kuppevelt TH, Martin PT, Fu H. McCarty DM, et al. Among authors: fu h. Metab Brain Dis. 2011 Mar;26(1):9-19. doi: 10.1007/s11011-010-9230-x. Epub 2011 Jan 12. Metab Brain Dis. 2011. PMID: 21225451 Free PMC article.

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