Kuhn I - Search Results

1

Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residues.

Kuhn I, Kellenberger E, Cakir-Kiefer C, Muller-Steffner H, Schuber F. Kuhn I, et al. Biochim Biophys Acta. 2014 Jul;1844(7):1317-31. doi: 10.1016/j.bbapap.2014.03.014. Epub 2014 Apr 8. Biochim Biophys Acta. 2014. PMID: 24721563

2

Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.

Kuhn I, Kellenberger E, Rognan D, Lund FE, Muller-Steffner H, Schuber F. Kuhn I, et al. Biochemistry. 2006 Oct 3;45(39):11867-78. doi: 10.1021/bi060930g. Biochemistry. 2006. PMID: 17002287 Free PMC article.

3

Identification of the N-glycosylation sites on recombinant bovine CD38 expressed in Pichia pastoris: their impact on enzyme stability and catalytic activity.

Muller-Steffner H, Kuhn I, Argentini M, Schuber F. Muller-Steffner H, et al. Among authors: kuhn i. Protein Expr Purif. 2010 Apr;70(2):151-7. doi: 10.1016/j.pep.2009.10.003. Epub 2009 Oct 7. Protein Expr Purif. 2010. PMID: 19818407

4

Flavonoids as inhibitors of human CD38.

Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H. Kellenberger E, et al. Among authors: kuhn i. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3939-42. doi: 10.1016/j.bmcl.2011.05.022. Epub 2011 May 14. Bioorg Med Chem Lett. 2011. PMID: 21641214

5

Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.

Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F. Egea PF, et al. Among authors: kuhn i. PLoS One. 2012;7(4):e34918. doi: 10.1371/journal.pone.0034918. Epub 2012 Apr 18. PLoS One. 2012. PMID: 22529956 Free PMC article.

6

Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis.

Kuhn I, Kellenberger E, Schuber F, Muller-Steffner H. Kuhn I, et al. Biochim Biophys Acta. 2013 Dec;1834(12):2520-7. doi: 10.1016/j.bbapap.2013.09.002. Epub 2013 Sep 12. Biochim Biophys Acta. 2013. PMID: 24035885

7

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.

Kuhn I, Kellenberger E, Said-Hassane F, Villa P, Rognan D, Lobstein A, Haiech J, Hibert M, Schuber F, Muller-Steffner H. Kuhn I, et al. Bioorg Med Chem. 2010 Nov 15;18(22):7900-10. doi: 10.1016/j.bmc.2010.09.041. Epub 2010 Sep 25. Bioorg Med Chem. 2010. PMID: 20951593

8

Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.

Jacques SA, Kuhn I, Koniev O, Schuber F, Lund FE, Wagner A, Muller-Steffner H, Kellenberger E. Jacques SA, et al. Among authors: kuhn i. J Med Chem. 2015 Apr 23;58(8):3582-92. doi: 10.1021/acs.jmedchem.5b00203. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25803425

9

Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.

Muller-Steffner H, Jacques SA, Kuhn I, Schultz MD, Botta D, Osswald P, Maechling C, Lund FE, Kellenberger E. Muller-Steffner H, et al. Among authors: kuhn i. ACS Chem Biol. 2017 Jul 21;12(7):1787-1795. doi: 10.1021/acschembio.7b00186. Epub 2017 May 17. ACS Chem Biol. 2017. PMID: 28481502

10

On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency.

Dovgan I, Ehkirch A, Lehot V, Kuhn I, Koniev O, Kolodych S, Hentz A, Ripoll M, Ursuegui S, Nothisen M, Cianférani S, Wagner A. Dovgan I, et al. Among authors: kuhn i. Sci Rep. 2020 May 6;10(1):7691. doi: 10.1038/s41598-020-64518-y. Sci Rep. 2020. PMID: 32376903 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

388 results

Search Page

Filters