Huang M - Search Results

1

Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1).

Chen F, Zhang G, Hong Z, Lin Z, Lei M, Huang M, Hu L. Chen F, et al. Among authors: huang m. Bioorg Med Chem Lett. 2014 May 15;24(10):2379-82. doi: 10.1016/j.bmcl.2014.03.045. Epub 2014 Mar 24. Bioorg Med Chem Lett. 2014. PMID: 24731276

2

Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.

Lin Z, Jiang L, Yuan C, Jensen JK, Zhang X, Luo Z, Furie BC, Furie B, Andreasen PA, Huang M. Lin Z, et al. Among authors: huang m. J Biol Chem. 2011 Mar 4;286(9):7027-32. doi: 10.1074/jbc.M110.204537. Epub 2011 Jan 3. J Biol Chem. 2011. PMID: 21199867 Free PMC article.

3

Structural basis for therapeutic intervention of uPA/uPAR system.

Ngo JC, Jiang L, Lin Z, Yuan C, Chen Z, Zhang X, Yu H, Wang J, Lin L, Huang M. Ngo JC, et al. Among authors: huang m. Curr Drug Targets. 2011 Nov;12(12):1729-43. doi: 10.2174/138945011797635911. Curr Drug Targets. 2011. PMID: 21707478 Review.

4

Structural insight into inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist.

Lin Z, Jensen JK, Hong Z, Shi X, Hu L, Andreasen PA, Huang M. Lin Z, et al. Among authors: huang m. Chem Biol. 2013 Feb 21;20(2):253-61. doi: 10.1016/j.chembiol.2013.01.002. Chem Biol. 2013. PMID: 23438754

5

Evaluation of interactions between urokinase plasminogen and inhibitors using molecular dynamic simulation and free-energy calculation.

Sa R, Fang L, Huang M, Li Q, Wei Y, Wu K. Sa R, et al. Among authors: huang m. J Phys Chem A. 2014 Oct 2;118(39):9113-9. doi: 10.1021/jp5064319. Epub 2014 Jul 9. J Phys Chem A. 2014. PMID: 24984238

6

Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1.

Gong L, Liu M, Zeng T, Shi X, Yuan C, Andreasen PA, Huang M. Gong L, et al. Among authors: huang m. J Biol Chem. 2015 Oct 23;290(43):25795-804. doi: 10.1074/jbc.M115.677567. Epub 2015 Aug 31. J Biol Chem. 2015. PMID: 26324706 Free PMC article.

7

Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor.

Xu P, Xu M, Jiang L, Yang Q, Luo Z, Dauter Z, Huang M, Andreasen PA. Xu P, et al. Among authors: huang m. J Med Chem. 2015 Nov 25;58(22):8868-76. doi: 10.1021/acs.jmedchem.5b01128. Epub 2015 Nov 12. J Med Chem. 2015. PMID: 26536069 Free PMC article.

8

A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase.

Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, Xue G, Yuan C, Lin L, Furie B, Flaumenhaft R, Andreasen P, Furie B, Huang M. Gong L, et al. Among authors: huang m. J Cell Mol Med. 2016 Oct;20(10):1851-60. doi: 10.1111/jcmm.12875. Epub 2016 May 20. J Cell Mol Med. 2016. PMID: 27197780 Free PMC article.

9

A long-acting PAI-1 inhibitor reduces thrombus formation.

Peng S, Xue G, Gong L, Fang C, Chen J, Yuan C, Chen Z, Yao L, Furie B, Huang M. Peng S, et al. Among authors: huang m. Thromb Haemost. 2017 Jun 28;117(7):1338-1347. doi: 10.1160/TH16-11-0891. Epub 2017 Apr 13. Thromb Haemost. 2017. PMID: 28405670

10

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.

Buckley BJ, Aboelela A, Minaei E, Jiang LX, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson DC, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, Kelso MJ. Buckley BJ, et al. Among authors: huang m. J Med Chem. 2018 Sep 27;61(18):8299-8320. doi: 10.1021/acs.jmedchem.8b00838. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30130401 Free PMC article.

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