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Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial.
Clarke JM, Simon GR, Mamdani H, Gu L, Herndon JE 2nd, Stinchcombe TE, Ready N, Crawford J, Sonpavde G, Balevic S, Nixon AB, Campa M, Gottlin EB, Li H, Saxena R, He YW, Antonia S, Patz EF Jr. Clarke JM, et al. Among authors: patz ef jr. Nat Commun. 2025 Jan 2;16(1):93. doi: 10.1038/s41467-024-55092-2. Nat Commun. 2025. PMID: 39747856 Free PMC article. Clinical Trial.
Upregulation of complement proteins in lung cancer cells mediates tumor progression.
Kleczko EK, Poczobutt JM, Navarro AC, Laskowski J, Johnson AM, Korpela SP, Gurule NJ, Heasley LE, Hopp K, Weiser-Evans MCM, Gottlin EB, Bushey RT, Campa MJ, Patz EF Jr, Thurman JM, Nemenoff RA. Kleczko EK, et al. Among authors: patz ef jr. Front Oncol. 2023 Jan 5;12:1045690. doi: 10.3389/fonc.2022.1045690. eCollection 2022. Front Oncol. 2023. PMID: 36686777 Free PMC article.
164 results