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Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment.
PLoS One. 2014 Apr 16;9(4):e94949. doi: 10.1371/journal.pone.0094949. eCollection 2014.
PLoS One. 2014.
PMID: 24740417
Free PMC article.
Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.
Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, O'rie T, Pienaar B, de Kock M, Kaplan G, Mahomed H, Dheda K, Hanekom WA.
Day CL, et al. Among authors: o rie t.
J Immunol. 2011 Sep 1;187(5):2222-32. doi: 10.4049/jimmunol.1101122. Epub 2011 Jul 20.
J Immunol. 2011.
PMID: 21775682
Free PMC article.
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