Deweese JE - Search Results

1

Etoposide quinone is a covalent poison of human topoisomerase IIβ.

Smith NA, Byl JA, Mercer SL, Deweese JE, Osheroff N. Smith NA, et al. Among authors: deweese je. Biochemistry. 2014 May 20;53(19):3229-36. doi: 10.1021/bi500421q. Epub 2014 May 2. Biochemistry. 2014. PMID: 24766193 Free PMC article.

2

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.

Deweese JE, Burgin AB, Osheroff N. Deweese JE, et al. Biochemistry. 2008 Apr 1;47(13):4129-40. doi: 10.1021/bi702194x. Epub 2008 Mar 5. Biochemistry. 2008. PMID: 18318502 Free PMC article.

3

Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.

Deweese JE, Burgin AB, Osheroff N. Deweese JE, et al. Nucleic Acids Res. 2008 Sep;36(15):4883-93. doi: 10.1093/nar/gkn466. Epub 2008 Jul 24. Nucleic Acids Res. 2008. PMID: 18653531 Free PMC article.

4

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.

Deweese JE, Osheroff N. Deweese JE, et al. Nucleic Acids Res. 2009 Feb;37(3):738-48. doi: 10.1093/nar/gkn937. Epub 2008 Nov 28. Nucleic Acids Res. 2009. PMID: 19042970 Free PMC article. Review.

5

Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.

Deweese JE, Osheroff N. Deweese JE, et al. Biochemistry. 2009 Feb 24;48(7):1439-41. doi: 10.1021/bi8021679. Biochemistry. 2009. PMID: 19166355 Free PMC article.

6

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

Deweese JE, Burch AM, Burgin AB, Osheroff N. Deweese JE, et al. Biochemistry. 2009 Mar 10;48(9):1862-9. doi: 10.1021/bi8023256. Biochemistry. 2009. PMID: 19222228 Free PMC article.

7

DNA Topology and Topoisomerases: Teaching a "Knotty" Subject.

Deweese JE, Osheroff MA, Osheroff N. Deweese JE, et al. Biochem Mol Biol Educ. 2008;37(1):2-10. doi: 10.1002/bmb.20244. Biochem Mol Biol Educ. 2008. PMID: 19225573 Free PMC article.

8

Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.

Deweese JE, Guengerich FP, Burgin AB, Osheroff N. Deweese JE, et al. Biochemistry. 2009 Sep 29;48(38):8940-7. doi: 10.1021/bi900875c. Biochemistry. 2009. PMID: 19697956 Free PMC article.

9

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.

Schmidt BH, Burgin AB, Deweese JE, Osheroff N, Berger JM. Schmidt BH, et al. Among authors: deweese je. Nature. 2010 Jun 3;465(7298):641-4. doi: 10.1038/nature08974. Nature. 2010. PMID: 20485342 Free PMC article.

10

The use of divalent metal ions by type II topoisomerases.

Deweese JE, Osheroff N. Deweese JE, et al. Metallomics. 2010 Jul;2(7):450-9. doi: 10.1039/c003759a. Epub 2010 May 21. Metallomics. 2010. PMID: 20703329 Free PMC article. Review.

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