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PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.
Hofmann C, Stühmer T, Schmiedl N, Wetzker R, Mottok A, Rosenwald A, Langer C, Zovko J, Chatterjee M, Einsele H, Bargou RC, Steinbrunn T. Hofmann C, et al. Among authors: steinbrunn t. Br J Haematol. 2014 Aug;166(4):529-39. doi: 10.1111/bjh.12920. Epub 2014 Apr 26. Br J Haematol. 2014. PMID: 24766330 Free article.
The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.
Chatterjee M, Andrulis M, Stühmer T, Müller E, Hofmann C, Steinbrunn T, Heimberger T, Schraud H, Kressmann S, Einsele H, Bargou RC. Chatterjee M, et al. Among authors: steinbrunn t. Haematologica. 2013 Jul;98(7):1132-41. doi: 10.3324/haematol.2012.066175. Epub 2012 Oct 12. Haematologica. 2013. PMID: 23065523 Free PMC article.
RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS.
Seibold M, Stühmer T, Kremer N, Mottok A, Scholz CJ, Schlosser A, Leich E, Holzgrabe U, Brünnert D, Barrio S, Kortüm MK, Solimando AG, Chatterjee M, Einsele H, Rosenwald A, Bargou RC, Steinbrunn T. Seibold M, et al. Among authors: steinbrunn t. Haematologica. 2020 Sep 1;105(9):2316-2326. doi: 10.3324/haematol.2019.223024. Haematologica. 2020. PMID: 33054056 Free PMC article.
Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules.
Leich E, Weißbach S, Klein HU, Grieb T, Pischimarov J, Stühmer T, Chatterjee M, Steinbrunn T, Langer C, Eilers M, Knop S, Einsele H, Bargou R, Rosenwald A. Leich E, et al. Among authors: steinbrunn t. Blood Cancer J. 2013 Feb 8;3(2):e102. doi: 10.1038/bcj.2012.47. Blood Cancer J. 2013. PMID: 23396385 Free PMC article.
A GRP78-Directed Monoclonal Antibody Recaptures Response in Refractory Multiple Myeloma with Extramedullary Involvement.
Rasche L, Menoret E, Dubljevic V, Menu E, Vanderkerken K, Lapa C, Steinbrunn T, Chatterjee M, Knop S, Düll J, Greenwood DL, Hensel F, Rosenwald A, Einsele H, Brändlein S. Rasche L, et al. Among authors: steinbrunn t. Clin Cancer Res. 2016 Sep 1;22(17):4341-9. doi: 10.1158/1078-0432.CCR-15-3111. Epub 2016 Mar 30. Clin Cancer Res. 2016. PMID: 27029491
25 results