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Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE. Kedzierski L, et al. Among authors: metcalf d. PLoS Pathog. 2014 May 8;10(5):e1004134. doi: 10.1371/journal.ppat.1004134. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24809749 Free PMC article.
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Nicholson SE, Metcalf D, Sprigg NS, Columbus R, Walker F, Silva A, Cary D, Willson TA, Zhang JG, Hilton DJ, Alexander WS, Nicola NA. Nicholson SE, et al. Among authors: metcalf d. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2328-33. doi: 10.1073/pnas.0409675102. Epub 2005 Feb 3. Proc Natl Acad Sci U S A. 2005. PMID: 15695332 Free PMC article.
IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.
Croker BA, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts AW. Croker BA, et al. Among authors: metcalf d. Immunol Cell Biol. 2012 Jan;90(1):124-9. doi: 10.1038/icb.2011.29. Epub 2011 Apr 26. Immunol Cell Biol. 2012. PMID: 21519345 Free PMC article.
Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.
Ushiki T, Huntington ND, Glaser SP, Kiu H, Georgiou A, Zhang JG, Metcalf D, Nicola NA, Roberts AW, Alexander WS. Ushiki T, et al. Among authors: metcalf d. PLoS One. 2016 Sep 1;11(9):e0162111. doi: 10.1371/journal.pone.0162111. eCollection 2016. PLoS One. 2016. PMID: 27583437 Free PMC article.
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Zhang JG, et al. Among authors: metcalf d. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2071-6. doi: 10.1073/pnas.96.5.2071. Proc Natl Acad Sci U S A. 1999. PMID: 10051596 Free PMC article.
777 results