Thurmond RL - Search Results

1

The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.

Kollmeier A, Francke K, Chen B, Dunford PJ, Greenspan AJ, Xia Y, Xu XL, Zhou B, Thurmond RL. Kollmeier A, et al. Among authors: thurmond rl. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7. doi: 10.1124/jpet.114.215749. Epub 2014 May 9. J Pharmacol Exp Ther. 2014. PMID: 24817035 Clinical Trial.

2

Phase 2a, randomized, double-blind, placebo-controlled, multicentre, parallel-group study of an H₄ R-antagonist (JNJ-39758979) in adults with uncontrolled asthma.

Kollmeier AP, Greenspan A, Xu XL, Silkoff PE, Barnathan ES, Loza MJ, Jiang J, Zhou B, Chen B, Thurmond RL. Kollmeier AP, et al. Among authors: thurmond rl. Clin Exp Allergy. 2018 Aug;48(8):957-969. doi: 10.1111/cea.13154. Epub 2018 Jun 6. Clin Exp Allergy. 2018. PMID: 29682796 Clinical Trial.

3

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. Thurmond RL, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. doi: 10.1124/jpet.103.061754. Epub 2004 Jan 13. J Pharmacol Exp Ther. 2004. PMID: 14722321

4

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.

Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Dunford PJ, et al. Among authors: thurmond rl. J Allergy Clin Immunol. 2007 Jan;119(1):176-83. doi: 10.1016/j.jaci.2006.08.034. Epub 2006 Oct 13. J Allergy Clin Immunol. 2007. PMID: 17208599

5

The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders.

Zhang M, Thurmond RL, Dunford PJ. Zhang M, et al. Among authors: thurmond rl. Pharmacol Ther. 2007 Mar;113(3):594-606. doi: 10.1016/j.pharmthera.2006.11.008. Epub 2006 Dec 28. Pharmacol Ther. 2007. PMID: 17275092 Review.

6

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.

Thurmond RL, Gelfand EW, Dunford PJ. Thurmond RL, et al. Nat Rev Drug Discov. 2008 Jan;7(1):41-53. doi: 10.1038/nrd2465. Nat Rev Drug Discov. 2008. PMID: 18172439 Review.

7

The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation.

Cowden JM, Zhang M, Dunford PJ, Thurmond RL. Cowden JM, et al. Among authors: thurmond rl. J Invest Dermatol. 2010 Apr;130(4):1023-33. doi: 10.1038/jid.2009.358. Epub 2009 Nov 12. J Invest Dermatol. 2010. PMID: 19907432 Free article.

8

Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.

Thurmond RL, Chen B, Dunford PJ, Greenspan AJ, Karlsson L, La D, Ward P, Xu XL. Thurmond RL, et al. J Pharmacol Exp Ther. 2014 May;349(2):176-84. doi: 10.1124/jpet.113.211714. Epub 2014 Feb 18. J Pharmacol Exp Ther. 2014. PMID: 24549371 Clinical Trial.

9

Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.

Murata Y, Song M, Kikuchi H, Hisamichi K, Xu XL, Greenspan A, Kato M, Chiou CF, Kato T, Guzzo C, Thurmond RL, Ohtsuki M, Furue M. Murata Y, et al. Among authors: thurmond rl. J Dermatol. 2015 Feb;42(2):129-39. doi: 10.1111/1346-8138.12726. Epub 2014 Dec 9. J Dermatol. 2015. PMID: 25491792 Clinical Trial.

10

Antihistamines and itch.

Thurmond RL, Kazerouni K, Chaplan SR, Greenspan AJ. Thurmond RL, et al. Handb Exp Pharmacol. 2015;226:257-90. doi: 10.1007/978-3-662-44605-8_15. Handb Exp Pharmacol. 2015. PMID: 25861785 Review.

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