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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC. Sabouri Z, et al. Among authors: rouet r. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821781 Free PMC article. Clinical Trial.
Rapid prediction of expression and refolding yields using phage display.
Dudgeon K, Rouet R, Christ D. Dudgeon K, et al. Among authors: rouet r. Protein Eng Des Sel. 2013 Oct;26(10):671-4. doi: 10.1093/protein/gzt019. Epub 2013 May 19. Protein Eng Des Sel. 2013. PMID: 23690626
We have recently identified mutations that control the aggregation behavior of human antibody variable domains (Dudgeon K., Rouet R., Kokmeijer I., Schofield P., Stolp J., Langley D., Stock D. and Christ D. (2012) Proc Natl Acad Sci USA, 109, 10879-10884. ...
We have recently identified mutations that control the aggregation behavior of human antibody variable domains (Dudgeon K., Rouet …
Stability engineering of the human antibody repertoire.
Rouet R, Lowe D, Christ D. Rouet R, et al. FEBS Lett. 2014 Jan 21;588(2):269-77. doi: 10.1016/j.febslet.2013.11.029. Epub 2013 Nov 28. FEBS Lett. 2014. PMID: 24291820 Free article. Review.
86 results