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Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
Liepinsh E, Makrecka M, Kuka J, Cirule H, Makarova E, Sevostjanovs E, Grinberga S, Vilskersts R, Lola D, Loza E, Stonans I, Pugovics O, Dambrova M. Liepinsh E, et al. Among authors: lola d. Pharmacol Res. 2014 Jul;85:33-8. doi: 10.1016/j.phrs.2014.05.002. Epub 2014 May 14. Pharmacol Res. 2014. PMID: 24836867
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
Andrianov V, Gailite V, Lola D, Loza E, Semenikhina V, Kalvinsh I, Finn P, Petersen KD, Ritchie JW, Khan N, Tumber A, Collins LS, Vadlamudi SM, Björkling F, Sehested M. Andrianov V, et al. Among authors: lola d. Eur J Med Chem. 2009 Mar;44(3):1067-85. doi: 10.1016/j.ejmech.2008.06.020. Epub 2008 Jun 27. Eur J Med Chem. 2009. PMID: 18672316
Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction.
Liepinsh E, Makrecka-Kuka M, Kuka J, Vilskersts R, Makarova E, Cirule H, Loza E, Lola D, Grinberga S, Pugovics O, Kalvins I, Dambrova M. Liepinsh E, et al. Among authors: lola d. Br J Pharmacol. 2015 Mar;172(5):1319-32. doi: 10.1111/bph.13004. Epub 2015 Jan 12. Br J Pharmacol. 2015. PMID: 25363063 Free PMC article.
N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.
Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW. Charlton MH, et al. Among authors: lola d. ACS Med Chem Lett. 2018 Jan 18;9(2):84-88. doi: 10.1021/acsmedchemlett.7b00374. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456792 Free PMC article.
Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors.
Benediktsdottir A, Sooriyaarachchi S, Cao S, Ottosson NE, Lindström S, Lundgren B, Kloditz K, Lola D, Bobileva O, Loza E, Hughes D, Jones TA, Mowbray SL, Zamaratski E, Sandström A, Karlén A. Benediktsdottir A, et al. Among authors: lola d. Eur J Med Chem. 2024 Nov 15;278:116790. doi: 10.1016/j.ejmech.2024.116790. Epub 2024 Aug 22. Eur J Med Chem. 2024. PMID: 39236497 Free article.
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