Liu H - Search Results

1

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.

Colis L, Ernst G, Sanders S, Liu H, Sirajuddin P, Peltonen K, DePasquale M, Barrow JC, Laiho M. Colis L, et al. Among authors: liu h. J Med Chem. 2014 Jun 12;57(11):4950-61. doi: 10.1021/jm5004842. Epub 2014 May 30. J Med Chem. 2014. PMID: 24847734 Free PMC article.

2

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Peltonen K, Colis L, Liu H, Jäämaa S, Moore HM, Enbäck J, Laakkonen P, Vaahtokari A, Jones RJ, af Hällström TM, Laiho M. Peltonen K, et al. Among authors: liu h. PLoS One. 2010 Sep 27;5(9):e12996. doi: 10.1371/journal.pone.0012996. PLoS One. 2010. PMID: 20885994 Free PMC article.

3

Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture.

Zhang Z, Yang Z, Jäämaa S, Liu H, Pellakuru LG, Iwata T, af Hällström TM, De Marzo AM, Laiho M. Zhang Z, et al. Among authors: liu h. Cell Cycle. 2011 Oct 15;10(20):3545-53. doi: 10.4161/cc.10.20.17841. Epub 2011 Oct 15. Cell Cycle. 2011. PMID: 22030624 Free PMC article.

4

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, Bai B, Rudek MA, Bieberich CJ, Laiho M. Peltonen K, et al. Among authors: liu h. Cancer Cell. 2014 Jan 13;25(1):77-90. doi: 10.1016/j.ccr.2013.12.009. Cancer Cell. 2014. PMID: 24434211 Free PMC article.

5

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs.

Bai B, Liu H, Laiho M. Bai B, et al. Among authors: liu h. FEBS Open Bio. 2014 May 2;4:441-9. doi: 10.1016/j.fob.2014.04.010. eCollection 2014. FEBS Open Bio. 2014. PMID: 24918059 Free PMC article.

6

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response.

Colis L, Peltonen K, Sirajuddin P, Liu H, Sanders S, Ernst G, Barrow JC, Laiho M. Colis L, et al. Among authors: liu h. Oncotarget. 2014 Jun 30;5(12):4361-9. doi: 10.18632/oncotarget.2020. Oncotarget. 2014. PMID: 24952786 Free PMC article.

7

Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.

Peltonen K, Colis L, Liu H, Jäämaa S, Zhang Z, Af Hällström T, Moore HM, Sirajuddin P, Laiho M. Peltonen K, et al. Among authors: liu h. Mol Cancer Ther. 2014 Nov;13(11):2537-46. doi: 10.1158/1535-7163.MCT-14-0256. Epub 2014 Oct 2. Mol Cancer Ther. 2014. PMID: 25277384 Free PMC article.

8

Novel Assay to Detect RNA Polymerase I Activity In Vivo.

Guner G, Sirajuddin P, Zheng Q, Bai B, Brodie A, Liu H, Af Hällström T, Kulac I, Laiho M, De Marzo AM. Guner G, et al. Among authors: liu h. Mol Cancer Res. 2017 May;15(5):577-584. doi: 10.1158/1541-7786.MCR-16-0246. Epub 2017 Jan 23. Mol Cancer Res. 2017. PMID: 28119429 Free PMC article.

9

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.

Wei T, Najmi SM, Liu H, Peltonen K, Kucerova A, Schneider DA, Laiho M. Wei T, et al. Among authors: liu h. Cell Rep. 2018 Apr 10;23(2):404-414. doi: 10.1016/j.celrep.2018.03.066. Cell Rep. 2018. PMID: 29642000 Free PMC article.

10

Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.

Low JY, Sirajuddin P, Moubarek M, Agarwal S, Rege A, Guner G, Liu H, Yang Z, De Marzo AM, Bieberich C, Laiho M. Low JY, et al. Among authors: liu h. Prostate. 2019 Dec;79(16):1837-1851. doi: 10.1002/pros.23909. Epub 2019 Sep 16. Prostate. 2019. PMID: 31524299 Free PMC article.

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