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Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation.
Sui X, Xu Y, Yang J, Fang Y, Lou H, Han W, Zhang M, Chen W, Wang K, Li D, Jin W, Lou F, Zheng Y, Hu H, Gong L, Zhou X, Pan Q, Pan H, Wang X, He C. Sui X, et al. Among authors: zheng y. PLoS One. 2014 May 21;9(5):e97781. doi: 10.1371/journal.pone.0097781. eCollection 2014. PLoS One. 2014. PMID: 24849329 Free PMC article.
JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy.
Sui X, Kong N, Wang X, Fang Y, Hu X, Xu Y, Chen W, Wang K, Li D, Jin W, Lou F, Zheng Y, Hu H, Gong L, Zhou X, Pan H, Han W. Sui X, et al. Among authors: zheng y. Sci Rep. 2014 Apr 15;4:4694. doi: 10.1038/srep04694. Sci Rep. 2014. Retraction in: Sci Rep. 2021 Feb 09;11(1):3797. doi: 10.1038/s41598-021-82870-5 PMID: 24733045 Free PMC article. Retracted.
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