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Page 1
Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.
European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI); van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G, Cihan B, Karadağ H, Soygür H, Cankurtaran EŞ, Ulusoy S, Akdede B, Binbay T, Ayer A, Noyan H, Karadayı G, Akturan E, Ulaş H, Arango C, Parellada M, Bernardo M, Sanjuán J, Bobes J, Arrojo M, Santos JL, Cuadrado P, Rodríguez Solano JJ, Carracedo A, García Bernardo E, Roldán L, López G, Cabrera B, Cruz S, Díaz Mesa EM, Pouso M, Jiménez E, Sánchez T, Rapado M, González E, Martínez C, Sánchez E, Olmeda MS, de Haan L, Velthorst E, van der Gaag M, Selten JP, van Dam D, van der Ven E, van der Meer F, Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, J… See abstract for full author list ➔ European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI), et al. Among authors: humphreys i. Schizophr Bull. 2014 Jul;40(4):729-36. doi: 10.1093/schbul/sbu069. Epub 2014 May 24. Schizophr Bull. 2014. PMID: 24860087 Free PMC article. Review.
De novo mutations in schizophrenia implicate synaptic networks.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC. Fromer M, et al. Among authors: humphreys i. Nature. 2014 Feb 13;506(7487):179-84. doi: 10.1038/nature12929. Epub 2014 Jan 22. Nature. 2014. PMID: 24463507 Free PMC article.
Protein interactions in human pathogens revealed through deep learning.
Humphreys IR, Zhang J, Baek M, Wang Y, Krishnakumar A, Pei J, Anishchenko I, Tower CA, Jackson BA, Warrier T, Hung DT, Peterson SB, Mougous JD, Cong Q, Baker D. Humphreys IR, et al. Nat Microbiol. 2024 Oct;9(10):2642-2652. doi: 10.1038/s41564-024-01791-x. Epub 2024 Sep 18. Nat Microbiol. 2024. PMID: 39294458 Free PMC article.
Computational design of serine hydrolases.
Lauko A, Pellock SJ, Anischanka I, Sumida KH, Juergens D, Ahern W, Shida A, Hunt A, Kalvet I, Norn C, Humphreys IR, Jamieson C, Kang A, Brackenbrough E, Bera AK, Sankaran B, Houk KN, Baker D. Lauko A, et al. Among authors: humphreys ir. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610411. doi: 10.1101/2024.08.29.610411. bioRxiv. 2024. PMID: 39257749 Free PMC article. Preprint.
A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications.
Bliss CM, Hulin-Curtis SL, Williams M, Marušková M, Davies JA, Statkute E, Baker AT, Stack L, Kerstetter L, Kerr-Jones LE, Milward KF, Russell G, George SJ, Badder LM, Stanton RJ, Coughlan L, Humphreys IR, Parker AL. Bliss CM, et al. Among authors: humphreys ir. Mol Ther Methods Clin Dev. 2024 Jul 30;32(3):101308. doi: 10.1016/j.omtm.2024.101308. eCollection 2024 Sep 12. Mol Ther Methods Clin Dev. 2024. PMID: 39206304 Free PMC article.
University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy: A prospective, multicenter study.
Maoz SL, Golzar A, Choby G, Hwang PH, Wang EW, Kuan EC, Adappa ND, Geltzeiler M, Getz AE, Humphreys IM, Le CH, Pinheiro-Neto CD, Fischer JL, Chan EP, Abuzeid WM, Chang EH, Jafari A, Kingdom TT, Kohanski MA, Lee JK, Lazor JW, Nabavizadeh A, Nayak JV, Palmer JN, Patel ZM, Resnick AC, Smith TL, Snyderman CH, St John MA, Storm PB, Suh JD, Wang MB, Sim MS, Beswick DM. Maoz SL, et al. Among authors: humphreys im. Int Forum Allergy Rhinol. 2024 Oct;14(10):1568-1581. doi: 10.1002/alr.23386. Epub 2024 Jun 17. Int Forum Allergy Rhinol. 2024. PMID: 38884276
A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.
Hulin-Curtis S, Geary JK, MacLachlan BJ, Altmann DM, Baillon L, Cole DK, Greenshields-Watson A, Hesketh SJ, Humphreys IR, Jones IM, Lauder SN, Mason GH, Smart K, Scourfield DO, Scott J, Sukhova K, Stanton RJ, Wall A, Rizkallah PJ, Barclay WS, Gallimore A, Godkin A. Hulin-Curtis S, et al. Among authors: humphreys ir. Cell Rep. 2024 Jun 25;43(6):114259. doi: 10.1016/j.celrep.2024.114259. Epub 2024 May 30. Cell Rep. 2024. PMID: 38819988 Free article.
Rapid and accurate prediction of protein homo-oligomer symmetry with Seq2Symm.
Kshirsagar M, Meller A, Humphreys I, Sledzieski S, Xu Y, Dodhia R, Horvitz E, Berger B, Bowman G, Ferres JL, Baker D, Baek M. Kshirsagar M, et al. Among authors: humphreys i. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-4215086. doi: 10.21203/rs.3.rs-4215086/v1. Res Sq. 2024. PMID: 38746169 Free PMC article. Preprint.
Essential and virulence-related protein interactions of pathogens revealed through deep learning.
Humphreys IR, Zhang J, Baek M, Wang Y, Krishnakumar A, Pei J, Anishchenko I, Tower CA, Jackson BA, Warrier T, Hung DT, Peterson SB, Mougous JD, Cong Q, Baker D. Humphreys IR, et al. bioRxiv [Preprint]. 2024 Apr 12:2024.04.12.589144. doi: 10.1101/2024.04.12.589144. bioRxiv. 2024. Update in: Nat Microbiol. 2024 Oct;9(10):2642-2652. doi: 10.1038/s41564-024-01791-x PMID: 38645026 Free PMC article. Updated. Preprint.
194 results