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136 results

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Page 1
Discovery of novel benzoxaborole-based potent antitrypanosomal agents.
Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ. Ding D, et al. Among authors: bacchi cj. ACS Med Chem Lett. 2010 Apr 6;1(4):165-9. doi: 10.1021/ml100013s. eCollection 2010 Jul 8. ACS Med Chem Lett. 2010. PMID: 24900190 Free PMC article.
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.
Nare B, Wring S, Bacchi C, Beaudet B, Bowling T, Brun R, Chen D, Ding C, Freund Y, Gaukel E, Hussain A, Jarnagin K, Jenks M, Kaiser M, Mercer L, Mejia E, Noe A, Orr M, Parham R, Plattner J, Randolph R, Rattendi D, Rewerts C, Sligar J, Yarlett N, Don R, Jacobs R. Nare B, et al. Antimicrob Agents Chemother. 2010 Oct;54(10):4379-88. doi: 10.1128/AAC.00498-10. Epub 2010 Jul 26. Antimicrob Agents Chemother. 2010. PMID: 20660666 Free PMC article.
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.
Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore JA 3rd, Nare B, Nguyen TM, Noe RA, Randolph R, Rewerts C, Wring SA, Yarlett N, Jacobs RT. Perales JB, et al. Among authors: bacchi cj. Bioorg Med Chem Lett. 2011 May 15;21(10):2816-9. doi: 10.1016/j.bmcl.2011.03.097. Epub 2011 Apr 1. Bioorg Med Chem Lett. 2011. PMID: 21507639
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Jacobs RT, Nare B, Wring SA, Orr MD, Chen D, Sligar JM, Jenks MX, Noe RA, Bowling TS, Mercer LT, Rewerts C, Gaukel E, Owens J, Parham R, Randolph R, Beaudet B, Bacchi CJ, Yarlett N, Plattner JJ, Freund Y, Ding C, Akama T, Zhang YK, Brun R, Kaiser M, Scandale I, Don R. Jacobs RT, et al. Among authors: bacchi cj. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151. doi: 10.1371/journal.pntd.0001151. Epub 2011 Jun 28. PLoS Negl Trop Dis. 2011. PMID: 21738803 Free PMC article.
Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.
Jacobs RT, Plattner JJ, Nare B, Wring SA, Chen D, Freund Y, Gaukel EG, Orr MD, Perales JB, Jenks M, Noe RA, Sligar JM, Zhang YK, Bacchi CJ, Yarlett N, Don R. Jacobs RT, et al. Among authors: bacchi cj. Future Med Chem. 2011 Aug;3(10):1259-78. doi: 10.4155/fmc.11.80. Future Med Chem. 2011. PMID: 21859301
Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis.
Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, Don R. Wring S, et al. Parasitology. 2014 Jan;141(1):104-18. doi: 10.1017/S003118201300098X. Epub 2013 Sep 5. Parasitology. 2014. PMID: 24007596 Free PMC article. Review.
Parasite polyamine metabolism: targets for chemotherapy.
Yarlett N, Bacchi CJ. Yarlett N, et al. Among authors: bacchi cj. Biochem Soc Trans. 1994 Nov;22(4):875-9. doi: 10.1042/bst0220875. Biochem Soc Trans. 1994. PMID: 7698477 Review. No abstract available.
136 results