Gadek TR - Search Results

1

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.

Zhong M, Gadek TR, Bui M, Shen W, Burnier J, Barr KJ, Hanan EJ, Oslob JD, Yu CH, Zhu J, Arkin MR, Evanchik MJ, Flanagan WM, Hoch U, Hyde J, Prabhu S, Silverman JA, Wright J. Zhong M, et al. Among authors: gadek tr. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6. doi: 10.1021/ml2002482. eCollection 2012 Mar 8. ACS Med Chem Lett. 2012. PMID: 24900456 Free PMC article.

2

Safety and pharmacokinetics of a novel lymphocyte function-associated antigen-1 antagonist ophthalmic solution (SAR 1118) in healthy adults.

Semba CP, Swearingen D, Smith VL, Newman MS, O'Neill CA, Burnier JP, Haughey DB, Gadek TR. Semba CP, et al. Among authors: gadek tr. J Ocul Pharmacol Ther. 2011 Feb;27(1):99-104. doi: 10.1089/jop.2009.0105. Epub 2010 Mar 24. J Ocul Pharmacol Ther. 2011. PMID: 20334535 Clinical Trial.

3

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR. Burdick DJ, et al. Among authors: gadek tr. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8. doi: 10.1016/s0960-894x(03)00084-2. Bioorg Med Chem Lett. 2003. PMID: 12643901

4

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR. Burdick DJ, et al. Among authors: gadek tr. Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9. doi: 10.1016/j.bmcl.2004.02.046. Bioorg Med Chem Lett. 2004. PMID: 15080978

5

Cyclic RGD peptide analogues as antiplatelet antithrombotics.

Barker PL, Bullens S, Bunting S, Burdick DJ, Chan KS, Deisher T, Eigenbrot C, Gadek TR, Gantzos R, Lipari MT, et al. Barker PL, et al. Among authors: gadek tr. J Med Chem. 1992 May 29;35(11):2040-8. doi: 10.1021/jm00089a014. J Med Chem. 1992. PMID: 1597855

6

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.

Khojasteh SC, Leipold DD, Lai F, La H, Baumgardner MJ, Desino KE, Gudmundsson OS, Bloedow DC, Bodary SC, Reynolds ME, Gadek TR, Kenkare-Mitra S. Khojasteh SC, et al. Among authors: gadek tr. Xenobiotica. 2008 Mar;38(3):340-52. doi: 10.1080/00498250701813248. Xenobiotica. 2008. PMID: 18274961

7

Discovery of novel PTP1b inhibitors.

Ockey DA, Gadek TR. Ockey DA, et al. Among authors: gadek tr. Bioorg Med Chem Lett. 2004 Jan 19;14(2):389-91. doi: 10.1016/j.bmcl.2003.10.058. Bioorg Med Chem Lett. 2004. PMID: 14698165

8

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Gadek TR, et al. Science. 2002 Feb 8;295(5557):1086-9. doi: 10.1126/science.295.5557.1086. Science. 2002. PMID: 11834839

9

Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118).

Sun Y, Zhang R, Gadek TR, O'Neill CA, Pearlman E. Sun Y, et al. Among authors: gadek tr. J Ocul Pharmacol Ther. 2013 May;29(4):395-402. doi: 10.1089/jop.2012.0102. Epub 2012 Dec 5. J Ocul Pharmacol Ther. 2013. PMID: 23215542 Free PMC article.

10

Safety, tolerability, and bioavailability of topical SAR 1118, a novel antagonist of lymphocyte function-associated antigen-1: a phase 1b study.

Paskowitz DM, Nguyen QD, Gehlbach P, Handa JT, Solomon S, Stark W, Shaikh O, Semba C, Gadek TR, Do DV. Paskowitz DM, et al. Among authors: gadek tr. Eye (Lond). 2012 Jul;26(7):944-9. doi: 10.1038/eye.2012.68. Epub 2012 Apr 27. Eye (Lond). 2012. PMID: 22538219 Free PMC article. Clinical Trial.

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