Najmanovich R - Search Results

1

Design and synthesis of potent, selective inhibitors of matriptase.

Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. Colombo E, et al. Among authors: najmanovich r. ACS Med Chem Lett. 2012 Apr 11;3(7):530-4. doi: 10.1021/ml3000534. eCollection 2012 Jul 12. ACS Med Chem Lett. 2012. PMID: 24900505 Free PMC article.

2

Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.

Duchêne D, Colombo E, Désilets A, Boudreault PL, Leduc R, Marsault E, Najmanovich R. Duchêne D, et al. Among authors: najmanovich r. J Med Chem. 2014 Dec 11;57(23):10198-204. doi: 10.1021/jm5015633. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25387268

3

Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.

St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É. St-Georges C, et al. Among authors: najmanovich rj. Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11. Eur J Med Chem. 2017. PMID: 28219045

4

Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines.

Dion SP, Béliveau F, Morency LP, Désilets A, Najmanovich R, Leduc R. Dion SP, et al. Among authors: najmanovich r. Sci Rep. 2018 Aug 22;8(1):12562. doi: 10.1038/s41598-018-30618-z. Sci Rep. 2018. PMID: 30135444 Free PMC article.

5

Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.

Yan LH, Le Roux A, Boyapelly K, Lamontagne AM, Archambault MA, Picard-Jean F, Lalonde-Seguin D, St-Pierre E, Najmanovich RJ, Fortier LC, Lafontaine D, Marsault É. Yan LH, et al. Eur J Med Chem. 2018 Jan 1;143:755-768. doi: 10.1016/j.ejmech.2017.11.079. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29220796

6

Large-scale analysis of conserved rare codon clusters suggests an involvement in co-translational molecular recognition events.

Chartier M, Gaudreault F, Najmanovich R. Chartier M, et al. Among authors: najmanovich r. Bioinformatics. 2012 Jun 1;28(11):1438-45. doi: 10.1093/bioinformatics/bts149. Epub 2012 Mar 30. Bioinformatics. 2012. PMID: 22467916 Free PMC article.

7

NRGsuite: a PyMOL plugin to perform docking simulations in real time using FlexAID.

Gaudreault F, Morency LP, Najmanovich RJ. Gaudreault F, et al. Bioinformatics. 2015 Dec 1;31(23):3856-8. doi: 10.1093/bioinformatics/btv458. Epub 2015 Aug 6. Bioinformatics. 2015. PMID: 26249810 Free PMC article.

8

Identification of an alternative translation initiation site in the sequence of the commonly used Glutathione S-Transferase tag.

Bernier SC, Morency LP, Najmanovich R, Salesse C. Bernier SC, et al. Among authors: najmanovich r. J Biotechnol. 2018 Nov 20;286:14-16. doi: 10.1016/j.jbiotec.2018.09.003. Epub 2018 Sep 6. J Biotechnol. 2018. PMID: 30195923

9

Applications of the NRGsuite and the Molecular Docking Software FlexAID in Computational Drug Discovery and Design.

Morency LP, Gaudreault F, Najmanovich R. Morency LP, et al. Among authors: najmanovich r. Methods Mol Biol. 2018;1762:367-388. doi: 10.1007/978-1-4939-7756-7_18. Methods Mol Biol. 2018. PMID: 29594781

10

Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects.

Chartier M, Morency LP, Zylber MI, Najmanovich RJ. Chartier M, et al. BMC Pharmacol Toxicol. 2017 Apr 28;18(1):18. doi: 10.1186/s40360-017-0128-7. BMC Pharmacol Toxicol. 2017. PMID: 28449705 Free PMC article.

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