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High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production.
Heazlewood SY, Ahmad T, Cao B, Cao H, Domingues M, Sun X, Heazlewood CK, Li S, Williams B, Fulton M, White JF, Nebl T, Nefzger CM, Polo JM, Kile BT, Kraus F, Ryan MT, Sun YB, Choong PFM, Ellis SL, Anko ML, Nilsson SK. Heazlewood SY, et al. Among authors: sun yb, sun x. Nat Commun. 2023 Apr 13;14(1):2099. doi: 10.1038/s41467-023-37780-7. Nat Commun. 2023. PMID: 37055407 Free PMC article.
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening.
Patrick R, Naval-Sanchez M, Deshpande N, Huang Y, Zhang J, Chen X, Yang Y, Tiwari K, Esmaeili M, Tran M, Mohamed AR, Wang B, Xia D, Ma J, Bayliss J, Wong K, Hun ML, Sun X, Cao B, Cottle DL, Catterall T, Barzilai-Tutsch H, Troskie RL, Chen Z, Wise AF, Saini S, Soe YM, Kumari S, Sweet MJ, Thomas HE, Smyth IM, Fletcher AL, Knoblich K, Watt MJ, Alhomrani M, Alsanie W, Quinn KM, Merson TD, Chidgey AP, Ricardo SD, Yu D, Jardé T, Cheetham SW, Marcelle C, Nilsson SK, Nguyen Q, White MD, Nefzger CM. Patrick R, et al. Among authors: sun x. Cell Metab. 2024 Aug 6;36(8):1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006. Epub 2024 Jul 2. Cell Metab. 2024. PMID: 38959897 Free article.
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