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X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS. Molodtsov V, et al. J Med Chem. 2015 Apr 9;58(7):3156-71. doi: 10.1021/acs.jmedchem.5b00050. Epub 2015 Mar 23. J Med Chem. 2015. PMID: 25798859 Free PMC article.
Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro.
Bruhn-Olszewska B, Molodtsov V, Sobala M, Dylewski M, Murakami KS, Cashel M, Potrykus K. Bruhn-Olszewska B, et al. Among authors: molodtsov v. Biochim Biophys Acta Gene Regul Mech. 2018 Aug;1861(8):731-742. doi: 10.1016/j.bbagrm.2018.07.005. Epub 2018 Jul 18. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 30012465 Free PMC article.
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon CW, Jeeves RE, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova Y, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N. Mosaei H, et al. Among authors: molodtsov v. Mol Cell. 2018 Oct 18;72(2):263-274.e5. doi: 10.1016/j.molcel.2018.08.028. Epub 2018 Sep 20. Mol Cell. 2018. PMID: 30244835 Free PMC article.
46 results