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Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.
van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. van den Berge M, et al. Among authors: postma ds. Thorax. 2014 Jan;69(1):14-23. doi: 10.1136/thoraxjnl-2012-202878. Epub 2013 Aug 7. Thorax. 2014. PMID: 23925644 Free PMC article. Clinical Trial.
Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.
Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS. Lamontagne M, et al. Among authors: postma ds. Thorax. 2014 Nov;69(11):997-1004. doi: 10.1136/thoraxjnl-2014-205630. Epub 2014 Sep 2. Thorax. 2014. PMID: 25182044
Molecular mechanisms underlying variations in lung function: a systems genetics analysis.
Obeidat M, Hao K, Bossé Y, Nickle DC, Nie Y, Postma DS, Laviolette M, Sandford AJ, Daley DD, Hogg JC, Elliott WM, Fishbane N, Timens W, Hysi PG, Kaprio J, Wilson JF, Hui J, Rawal R, Schulz H, Stubbe B, Hayward C, Polasek O, Järvelin MR, Zhao JH, Jarvis D, Kähönen M, Franceschini N, North KE, Loth DW, Brusselle GG, Smith AV, Gudnason V, Bartz TM, Wilk JB, O'Connor GT, Cassano PA, Tang W, Wain LV, Soler Artigas M, Gharib SA, Strachan DP, Sin DD, Tobin MD, London SJ, Hall IP, Paré PD. Obeidat M, et al. Among authors: postma ds. Lancet Respir Med. 2015 Oct;3(10):782-95. doi: 10.1016/S2213-2600(15)00380-X. Epub 2015 Sep 21. Lancet Respir Med. 2015. PMID: 26404118 Free PMC article.
Impact of Statins on Gene Expression in Human Lung Tissues.
Lane J, van Eeden SF, Obeidat M, Sin DD, Tebbutt SJ, Timens W, Postma DS, Laviolette M, Paré PD, Bossé Y. Lane J, et al. Among authors: postma ds. PLoS One. 2015 Nov 4;10(11):e0142037. doi: 10.1371/journal.pone.0142037. eCollection 2015. PLoS One. 2015. PMID: 26535575 Free PMC article.
A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.
Spanjer AI, Menzen MH, Dijkstra AE, van den Berge M, Boezen HM, Nickle DC, Sin DD, Bossé Y, Brandsma CA, Timens W, Postma DS, Meurs H, Heijink IH, Gosens R. Spanjer AI, et al. Among authors: postma ds. Thorax. 2016 Apr;71(4):312-22. doi: 10.1136/thoraxjnl-2015-206958. Epub 2016 Jan 21. Thorax. 2016. PMID: 26797711
Lung tissue gene-expression signature for the ageing lung in COPD.
de Vries M, Faiz A, Woldhuis RR, Postma DS, de Jong TV, Sin DD, Bossé Y, Nickle DC, Guryev V, Timens W, van den Berge M, Brandsma CA. de Vries M, et al. Among authors: postma ds. Thorax. 2017 Dec 6:thoraxjnl-2017-210074. doi: 10.1136/thoraxjnl-2017-210074. Online ahead of print. Thorax. 2017. PMID: 29212667
897 results