Tyndale RF - Search Results

1

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.

Chenoweth MJ, Novalen M, Hawk LW Jr, Schnoll RA, George TP, Cinciripini PM, Lerman C, Tyndale RF. Chenoweth MJ, et al. Among authors: tyndale rf. Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1773-82. doi: 10.1158/1055-9965.EPI-14-0427. Epub 2014 Jul 10. Cancer Epidemiol Biomarkers Prev. 2014. PMID: 25012994 Free PMC article. Clinical Trial.

2

A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.

Tyndale RF, Pianezza ML, Sellers EM. Tyndale RF, et al. Nicotine Tob Res. 1999;1 Suppl 2:S63-7; discussion S69-70. doi: 10.1080/14622299050011831. Nicotine Tob Res. 1999. PMID: 11768189 Review.

This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if dependent, how impairment of the CYP2A6 gene function decreases the number of cigarettes consumed by smokers (Pianezza M, Sellers EM, Tyndale …

This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if depend …

3

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Miksys S, et al. Among authors: tyndale rf. Neuropharmacology. 2003 Jul;45(1):122-32. doi: 10.1016/s0028-3908(03)00136-9. Neuropharmacology. 2003. PMID: 12814665

4

Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity.

Dempsey D, Tutka P, Jacob P 3rd, Allen F, Schoedel K, Tyndale RF, Benowitz NL. Dempsey D, et al. Among authors: tyndale rf. Clin Pharmacol Ther. 2004 Jul;76(1):64-72. doi: 10.1016/j.clpt.2004.02.011. Clin Pharmacol Ther. 2004. PMID: 15229465

5

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF. Schoedel KA, et al. Among authors: tyndale rf. Pharmacogenetics. 2004 Sep;14(9):615-26. doi: 10.1097/00008571-200409000-00006. Pharmacogenetics. 2004. PMID: 15475735

6

Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy.

Malaiyandi V, Lerman C, Benowitz NL, Jepson C, Patterson F, Tyndale RF. Malaiyandi V, et al. Among authors: tyndale rf. Mol Psychiatry. 2006 Apr;11(4):400-9. doi: 10.1038/sj.mp.4001794. Mol Psychiatry. 2006. PMID: 16402128 Clinical Trial.

7

Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5.

Siu EC, Wildenauer DB, Tyndale RF. Siu EC, et al. Among authors: tyndale rf. Psychopharmacology (Berl). 2006 Mar;184(3-4):401-8. doi: 10.1007/s00213-006-0306-6. Epub 2006 Jan 28. Psychopharmacology (Berl). 2006. PMID: 16485141

8

Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics.

Al Koudsi N, Mwenifumbo JC, Sellers EM, Benowitz NL, Swan GE, Tyndale RF. Al Koudsi N, et al. Among authors: tyndale rf. Eur J Clin Pharmacol. 2006 Jun;62(6):481-4. doi: 10.1007/s00228-006-0113-3. Epub 2006 Apr 28. Eur J Clin Pharmacol. 2006. PMID: 16758265

9

Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation.

Lerman C, Tyndale R, Patterson F, Wileyto EP, Shields PG, Pinto A, Benowitz N. Lerman C, et al. Clin Pharmacol Ther. 2006 Jun;79(6):600-8. doi: 10.1016/j.clpt.2006.02.006. Epub 2006 May 11. Clin Pharmacol Ther. 2006. PMID: 16765148 Clinical Trial.

10

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.

Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF. Malaiyandi V, et al. Among authors: tyndale rf. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1812-9. doi: 10.1158/1055-9965.EPI-05-0723. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 17035386

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