Fischer H - Search Results

1

Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis.

Doessegger L, Schmitt G, Lenz B, Fischer H, Schlotterbeck G, Atzpodien EA, Senn H, Suter L, Csato M, Evers S, Singer T. Doessegger L, et al. Among authors: fischer h. Ther Adv Drug Saf. 2013 Jun;4(3):101-14. doi: 10.1177/2042098613479393. Ther Adv Drug Saf. 2013. PMID: 25083254 Free PMC article.

2

In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.

Fischer H, Atzpodien EA, Csato M, Doessegger L, Lenz B, Schmitt G, Singer T. Fischer H, et al. J Med Chem. 2012 Jan 12;55(1):126-39. doi: 10.1021/jm201082a. Epub 2012 Jan 4. J Med Chem. 2012. PMID: 22122484

3

Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt.

Lenz B, Brink A, Mihatsch MJ, Altmann B, Niederhauser U, Steinhuber B, Wyttenbach N, Fischer H. Lenz B, et al. Among authors: fischer h. Toxicol Sci. 2021 Apr 12;180(2):383-394. doi: 10.1093/toxsci/kfaa191. Toxicol Sci. 2021. PMID: 33454789 Free PMC article.

4

An aminomethylpyrimidine DPP-IV inhibitor with improved properties.

Peters JU, Hunziker D, Fischer H, Kansy M, Weber S, Kritter S, Müller A, Wallier A, Ricklin F, Boehringer M, Poli SM, Csato M, Loeffler BM. Peters JU, et al. Among authors: fischer h. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3575-8. doi: 10.1016/j.bmcl.2004.04.048. Bioorg Med Chem Lett. 2004. PMID: 15177477

5

Computational toxicology in drug development.

Muster W, Breidenbach A, Fischer H, Kirchner S, Müller L, Pähler A. Muster W, et al. Among authors: fischer h. Drug Discov Today. 2008 Apr;13(7-8):303-10. doi: 10.1016/j.drudis.2007.12.007. Epub 2008 Feb 20. Drug Discov Today. 2008. PMID: 18405842 Review.

6

Can we discover pharmacological promiscuity early in the drug discovery process?

Peters JU, Hert J, Bissantz C, Hillebrecht A, Gerebtzoff G, Bendels S, Tillier F, Migeon J, Fischer H, Guba W, Kansy M. Peters JU, et al. Among authors: fischer h. Drug Discov Today. 2012 Apr;17(7-8):325-35. doi: 10.1016/j.drudis.2012.01.001. Epub 2012 Jan 16. Drug Discov Today. 2012. PMID: 22269136 Review.

7

3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors.

Pinard E, Alberati D, Alvarez-Sanchez R, Brom V, Burner S, Fischer H, Hauser N, Kolczewski S, Lengyel J, Mory R, Saladin C, Schulz-Gasch T, Stalder H. Pinard E, et al. Among authors: fischer h. ACS Med Chem Lett. 2014 Feb 4;5(4):428-33. doi: 10.1021/ml500005m. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900853 Free PMC article.

8

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors.

Pinard E, Alberati D, Borroni E, Fischer H, Hainzl D, Jolidon S, Moreau JL, Narquizian R, Nettekoven M, Norcross RD, Stalder H, Thomas AW. Pinard E, et al. Among authors: fischer h. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5134-9. doi: 10.1016/j.bmcl.2008.07.086. Epub 2008 Jul 24. Bioorg Med Chem Lett. 2008. PMID: 18752953

9

β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.

Hilpert H, Guba W, Woltering TJ, Wostl W, Pinard E, Mauser H, Mayweg AV, Rogers-Evans M, Humm R, Krummenacher D, Muser T, Schnider C, Jacobsen H, Ozmen L, Bergadano A, Banner DW, Hochstrasser R, Kuglstatter A, David-Pierson P, Fischer H, Polara A, Narquizian R. Hilpert H, et al. Among authors: fischer h. J Med Chem. 2013 May 23;56(10):3980-95. doi: 10.1021/jm400225m. Epub 2013 May 2. J Med Chem. 2013. PMID: 23590342

10

Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P. Ratni H, et al. Among authors: fischer h. J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18. J Med Chem. 2015. PMID: 25654260

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