Osswald HL - Search Results

1

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.

Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC. Deng X, et al. Among authors: osswald hl. J Virol. 2014 Oct;88(20):11886-98. doi: 10.1128/JVI.01528-14. Epub 2014 Aug 6. J Virol. 2014. PMID: 25100843 Free PMC article.

2

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Ghosh AK, Osswald HL. Ghosh AK, et al. Among authors: osswald hl. Chem Soc Rev. 2014 Oct 7;43(19):6765-813. doi: 10.1039/c3cs60460h. Chem Soc Rev. 2014. PMID: 24691405 Free PMC article. Review.

3

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Tomar S, et al. Among authors: osswald hl. J Biol Chem. 2015 Aug 7;290(32):19403-22. doi: 10.1074/jbc.M115.651463. Epub 2015 Jun 8. J Biol Chem. 2015. PMID: 26055715 Free PMC article.

4

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

St John SE, Therkelsen MD, Nyalapatla PR, Osswald HL, Ghosh AK, Mesecar AD. St John SE, et al. Among authors: osswald hl. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5072-7. doi: 10.1016/j.bmcl.2015.10.023. Epub 2015 Oct 13. Bioorg Med Chem Lett. 2015. PMID: 26592814 Free PMC article.

5

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Ghosh AK, Osswald HL, Prato G. Ghosh AK, et al. Among authors: osswald hl. J Med Chem. 2016 Jun 9;59(11):5172-208. doi: 10.1021/acs.jmedchem.5b01697. Epub 2016 Jan 22. J Med Chem. 2016. PMID: 26799988 Free PMC article. Review.

6

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

Ghosh AK, Parham GL, Martyr CD, Nyalapatla PR, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: osswald hl. J Med Chem. 2013 Sep 12;56(17):6792-802. doi: 10.1021/jm400768f. Epub 2013 Aug 15. J Med Chem. 2013. PMID: 23947685 Free PMC article.

7

Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.

Ghosh AK, Schiltz GE, Rusere LN, Osswald HL, Walters DE, Amano M, Mitsuya H. Ghosh AK, et al. Among authors: osswald hl. Org Biomol Chem. 2014 Sep 21;12(35):6842-54. doi: 10.1039/c4ob00738g. Org Biomol Chem. 2014. PMID: 25050776 Free PMC article.

8

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

Ghosh AK, Yu X, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: osswald hl. J Med Chem. 2015 Jul 9;58(13):5334-43. doi: 10.1021/acs.jmedchem.5b00676. Epub 2015 Jun 24. J Med Chem. 2015. PMID: 26107245 Free PMC article.

9

Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization.

Ghosh AK, Xu CX, Osswald HL. Ghosh AK, et al. Among authors: osswald hl. Tetrahedron Lett. 2015 Jun 3;56(23):3314-3317. doi: 10.1016/j.tetlet.2015.01.019. Tetrahedron Lett. 2015. PMID: 26185337 Free PMC article.

10

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

Ghosh AK, Martyr CD, Osswald HL, Sheri VR, Kassekert LA, Chen S, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: osswald hl. J Med Chem. 2015 Sep 10;58(17):6994-7006. doi: 10.1021/acs.jmedchem.5b00900. Epub 2015 Aug 25. J Med Chem. 2015. PMID: 26306007 Free PMC article.

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